ReviewPlasmid2009
The RepA_N replicons of Gram-positive bacteria: a family of broadly distributed but narrow host range plasmids.
Review in Plasmid, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Investigating the mobility and host range of mobile genetic elements harbouring antimicrobial resistance genes in enterococci.Microbiology (Reading, England) · 2026Article
- Plasmidomic landscape of Staphylococcus aureus and the emergence of a CC5 subclade harboring the conjugative plasmid pSK41: implications for food safety and antimicrobial resistance.NPJ science of food · 2026Article
- Article
- ISMicrobial genomics · 2025Article
- Universal rules govern plasmid copy number.Nature communications · 2025Article
- Private and well drinking water are reservoirs for antimicrobial resistant bacteria.npj antimicrobials and resistance · 2024Article
- Polyether ionophore resistance in a one health perspective.Frontiers in microbiology · 2024Review
- High prevalence and plasmidome diversity ofFrontiers in microbiology · 2024Article
- Effect of TraN key residues involved in DNA binding on pIP501 transfer rates inFrontiers in molecular biosciences · 2024Article
- Phylogeny, Virulence, and Antimicrobial Resistance Gene Profiles ofAntibiotics (Basel, Switzerland) · 2023Article
- The Plasmidomic Landscape of Clinical Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Comparative Genomic Analysis of a Multidrug-ResistantPathogens (Basel, Switzerland) · 2022Article
- pLS20 is the archetype of a new family of conjugative plasmids harboured byNAR genomics and bioinformatics · 2021Article
- RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication.Frontiers in microbiology · 2021Article
- Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction.Nucleic acids research · 2020Article
- Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s.Antimicrobial agents and chemotherapy · 2019Article
- A Novel, WidespreadAntimicrobial agents and chemotherapy · 2019Article
- Enterococcal Genetics.Microbiology spectrum · 2019Review
- Staphylococcal Plasmids, Transposable and Integrative Elements.Microbiology spectrum · 2018Review
- Mobile Genetic Elements Associated with Antimicrobial Resistance.Clinical microbiology reviews · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The pheromone-responsive conjugative plasmids of Enterococcus faecalis and the multiresistance plasmids pSK1 and pSK41 of Staphylococcus aureus are among the best studied plasmids native to Gram-positive bacteria. Although these plasmids seem largely restricted to their native hosts, protein sequence comparison of their replication initiator proteins indicates that they are clearly related. Homology searches indicate that these replicons are representatives of a large family of plasmids and a few phage that are widespread among the low G+C Gram-positive bacteria. We propose to name this family the RepA_N family of replicons after the annotated conserved domain that the initiator protein contains. Detailed sequence comparisons indicate that the initiator protein phylogeny is largely congruent with that of the host, suggesting that the replicons have evolved along with their current hosts and that intergeneric transfer has been rare. However, related proteins were identified on chromosomal regions bearing characteristics indicative of ICE elements, and the phylogeny of these proteins displayed evidence of more frequent intergeneric transfer. Comparison of stability determinants associated with the RepA_N replicons suggests that they have a modular evolution as has been observed in other plasmid families.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.