ArticlePharmacology, biochemistry, and behavior2009
Methylphenidate potentiates morphine-induced antinociception, hyperthermia, and locomotor activity in young adult rats.
Article in Pharmacology, biochemistry, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Stimulant Treatment Gap in ADHD Patients with Heroin Use Disorder: Clinical and Behavioural Consequences.International journal of environmental research and public health · 2025Article
- Neuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats.Translational psychiatry · 2024Article
- Methylphenidate attenuates signs of evoked neuropathic pain in animal model.Physiological research · 2023Article
- Adult-Attention Deficit Hyperactive Disorder Symptoms Seem Not to Influence the Outcome of an Enhanced Agonist Opioid Treatment: A 30-Year Follow-Up.International journal of environmental research and public health · 2021Article
- Exposure to methylphenidate during peri-adolescence decouples the prefrontal cortex: a multimodal MRI study.American journal of translational research · 2021Article
- Enduring effects of adolescent ketamine exposure on cocaine- and sucrose-induced reward in male and female C57BL/6 mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Sex differences in α-pyrrolidinopentiophenone (α-PVP)-induced taste avoidance, place preference, hyperthermia and locomotor activity in rats.Pharmacology, biochemistry, and behavior · 2019Article
- Relief of Pain-Depressed Behavior in Rats by Activation of D1-Like Dopamine Receptors.The Journal of pharmacology and experimental therapeutics · 2017Article
- Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior.Progress in brain research · 2014Review
- Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period.Behavioural brain research · 2013Article
- Chronic psychostimulant exposure to adult, but not periadolescent rats reduces subsequent morphine antinociception.Pharmacology, biochemistry, and behavior · 2012Article
- Post-training cocaine exposure facilitates spatial memory consolidation in C57BL/6 mice.Hippocampus · 2012Article
- Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Early methylphenidate exposure enhances cocaine self-administration but not cocaine-induced conditioned place preference in young adult rats.Psychopharmacology · 2011Article
- Can behavioral sensory processing problems guide us to a better pharmacological management of children with attention deficit hyperactivity disorder?: a case report.Psychiatry (Edgmont (Pa. : Township)) · 2009Article
- Methylphenidate and μ opioid receptor interactions: a pharmacological target for prevention of stimulant abuse.NeuropharmacologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The goal of this study was to determine if the exaggerated morphine-induced conditioned place preference (CPP) response seen in adult rats after preweanling methylphenidate exposure is unique to reward-mediated behaviors or is indicative of generalized changes in opioid-mediated behaviors. Rats were exposed to saline or methylphenidate (2.0 or 5.0 mg/kg) for 10 consecutive days starting on postnatal (PD) 11 with testing beginning on PD 60. In Experiment 1, morphine-induced (0, 2.5, 5.0 or 10.0 mg/kg) antinociception was assessed using the tail immersion and hot plate tasks. In Experiment 2, morphine-induced (0, 2.5, 5.0, or 10.0 mg/kg) hyperthermia and locomotor activity were measured. Morphine caused an increase in antinociception, with early methylphenidate (5.0 mg/kg) exposure potentiating the effects of 5.0 mg/kg morphine. Rectal temperatures were elevated after morphine, with the greatest increase occurring in male rats. Methylphenidate potentiated the hyperthermic effects of morphine (10.0 mg/kg) but only in males. Moderate doses (2.5 and 5.0 mg/kg) of morphine increased the locomotor activity of adult rats, while a higher dose (10.0 mg/kg) decreased locomotion. Interestingly, methylphenidate-pretreated females showed increased locomotor activity relative to controls. These results suggest that early methylphenidate exposure induces general changes in opioid system functioning that are not specific to reward-mediated behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.