ArticlePsychopharmacology2009
Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Multisystem regulation of reward and addiction: beyond the dopaminergic system.Frontiers in pharmacology · 2026Review
- Δ 9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner.The international journal of neuropsychopharmacology · 2021Article
- Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.Brain research · 2016Review
- The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex.Addiction biology · 2015Article
- The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats.Psychopharmacology · 2015Article
- Orquestic regulation of neurotransmitters on reward-seeking behavior.International archives of medicine · 2014Review
- Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2.The European journal of neuroscience · 2013Article
- The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Galnon facilitates extinction of morphine-conditioned place preference but also potentiates the consolidation process.PloS one · 2013Article
- The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction.Nature neuroscience · 2012Review
- Galanin negatively modulates opiate withdrawal via galanin receptor 1.Psychopharmacology · 2012Article
- Ethanol modulation of gene networks: implications for alcoholism.Neurobiology of disease · 2012Review
- The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Enhanced cocaine-conditioned place preference and associated brain regional levels of BDNF, p-ERK1/2 and p-Ser845-GluA1 in food-restricted rats.Brain research · 2011Article
- The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference.Pharmacology, biochemistry, and behavior · 2011Article
- Locomotion and self-administration induced by cocaine in 129/OlaHsd mice lacking galanin.Behavioral neuroscience · 2010Article
- Dopamine-mediated MK-801-induced elevation in food-based extinction responding in rats and associated changes in region-specific phosphorylated ERK.Psychopharmacology · 2010Article
- Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors.Brain research · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe neuropeptide galanin and its receptors are expressed in brain regions implicated in the rewarding effects of natural stimuli and drugs of abuse. Galanin has been shown to attenuate neurochemical, physiological, and behavioral signs of opiate and amphetamine reinforcement.
objectiveIn the current study, we present evidence that galanin modulates neurochemical and behavioral correlates of cocaine response.
methodsMice lacking the neuropeptide galanin (Gal -/-) and wild-type (Gal +/+) controls were used to analyze the effects of galanin in an unbiased conditioned place preference paradigm. We then examined cocaine-induced activation of extracellular signal-regulated kinase (ERK) activity as a marker of intracellular signaling in the mesolimbic dopaminergic pathway induced by acute cocaine administration
resultsGal -/- mice showed significantly greater conditioned place preference at a threshold dose of cocaine (3 mg/kg) than Gal +/+ mice, and this was reversed by administration of the galanin receptor agonist galnon. Consistent with the results of behavioral experiments, there was a significant increase in ERK activation in the ventral tegmental area (VTA) and nucleus accumbens (NAc) of Gal -/- mice but not Gal +/+ mice following acute, systemic cocaine injection at the threshold dose. In the NAc, but not VTA, this effect was reversed by administration of galnon.
conclusionsThese data, coupled with previous studies on the effects of morphine and amphetamine, demonstrate that galanin normally attenuates drug reinforcement, potentially via modulation of the mesolimbic dopamine system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.