Evidence map›Paper›PMID 19098989›Full record

Trial reportPloS one2008

Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial.

Margaret Kweku, Dongmei Liu, Martin Adjuik, Fred Binka, Mahmood Seidu, Brian Greenwood, Daniel Chandramohan

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00119132 (A Study Of Impact Of Intermittent Preventive Treatment In Children With Amodiaquine Plus Artesunate Versus Sulphadoxine-Pyrimethamine On Hemoglobin Levels And Malaria Morbidity In Hohoe District Of Ghana), which is not on this map. Cited by 80 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 11 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00119132 phase2 / phase3completednot on this map

A Study Of Impact Of Intermittent Preventive Treatment In Children With Amodiaquine Plus Artesunate Versus Sulphadoxine-Pyrimethamine On Hemoglobin Levels And Malaria Morbidity In Hohoe District Of Ghana

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2005 to 2006Enrolled2,602ConditionsMalariaArmsartesunate-amodiaquine, sulphadoxine-pyrimethamine
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 11 syntheses or guidelines pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Systematic Review and Meta-Analysis of Seasonal Malaria Chemoprevention.The American journal of tropical medicine and hygiene · 2024
    Pooled it
  3. Pooled it
  4. Intermittent preventive treatment for malaria in infants.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Intermittent preventive treatment for malaria in infants.The Cochrane database of systematic reviews · 2019
    Pooled it
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  8. Intermittent preventive antimalarial treatment for children with anaemia.The Cochrane database of systematic reviews · 2015
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  9. Mass drug administration for malaria.The Cochrane database of systematic reviews · 2013
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  15. Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Margaret KwekuLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Dongmei Liu
Martin Adjuik
Fred Binka
Mahmood Seidu
Brian Greenwood
Daniel Chandramohan
London School of Hygiene & Tropical Medicine · GBUniversity of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria and anaemia are the leading causes of morbidity and mortality in children in sub-Saharan Africa. We have investigated the effect of intermittent preventive treatment with sulphadoxine-pyrimethamine or artesunate plus amodiaquine on anaemia and malaria in children in an area of intense, prolonged, seasonal malaria transmission in Ghana.

methods2451 children aged 3-59 months from 30 villages were individually randomised to receive placebo or artesunate plus amodiaquine (AS+AQ) monthly or bimonthly, or sulphadoxine-pyrimethamine (SP) bimonthly over a period of six months. The primary outcome measures were episodes of anaemia (Hb<8.0 g/dl) or malaria detected through passive surveillance.

findingsMonthly artesunate plus amodiaquine reduced the incidence of malaria by 69% (95% CI: 63%, 74%) and anaemia by 45% (95% CI: 25%,60%), bimonthly sulphadoxine-pyrimethamine reduced the incidence of malaria by 24% (95% CI: 14%,33%) and anaemia by 30% (95% CI: 6%, 49%) and bimonthly artesunate plus amodiaquine reduced the incidence of malaria by 17% (95% CI: 6%, 27%) and anaemia by 32% (95% CI: 7%, 50%) compared to placebo. There were no statistically significant reductions in the episodes of all cause or malaria specific hospital admissions in any of the intervention groups compared to the placebo group. There was no significant increase in the incidence of clinical malaria in the post intervention period in children who were >1 year old when they received IPTc compared to the placebo group. However the incidence of malaria in the post intervention period was higher in children who were <1 year old when they received AS+AQ monthly compared to the placebo group.

interpretationIPTc is safe and efficacious in reducing the burden of malaria in an area of Ghana with a prolonged, intense malaria transmission season.

trial registrationClinicalTrials.gov NCT00119132.

Indexed as

SeasonsAmodiaquineAnemiaAntimalarialsArtemisininsArtesunateChild, PreschoolDrug CombinationsGhanaHumansInfantKaplan-Meier EstimateMalariaPlacebosPyrimethamineSulfadoxineAmodiaquineAntimalarialsArtemisininsArtesunateDrug Combinationsfanasil, pyrimethamine drug combinationPlacebosPyrimethamineSulfadoxine

Identifiers

PMID19098989
PMCPMC2602973
OpenAlexW1974204803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.