ArticleNature medicine2009
Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder.
Article in Nature medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 148 citations in OpenAlex.
- TUBGCP2 variants cause lissencephaly spectrum disorders: a case report and literature review.Frontiers in pediatrics · 2025Article
- From bedside to bench: New insights in epilepsy-associated tumors based on recent classification updates and animal models on brain tumor networks.Molecular oncology · 2024Review
- CXCR5 Regulates Neuronal Polarity Development and Migration in the Embryonic Stage via F-Actin Homeostasis and Results in Epilepsy-Related Behavior.Neuroscience bulletin · 2023Article
- 5-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades.Frontiers in oncology · 2023Article
- Increased prevalence of minor physical anomalies in patients with epilepsy.Scientific reports · 2022Article
- Article
- The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse during Normal Development and after Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Creative Destruction: A Basic Computational Model of Cortical Layer Formation.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Article
- Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons.EMBO reports · 2020Article
- Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice.Acta neuropathologica communications · 2020Article
- Modulation of Coordinated Activity across Cortical Layers by Plasticity of Inhibitory Synapses.Cell reports · 2020Article
- Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.PLoS biology · 2020Article
- Identification and prevention of heterotopias in mouse neocortical neural cell migration incurred by surgical damages during utero electroporation procedures.Animal cells and systems · 2020Article
- Strong preference for autaptic self-connectivity of neocortical PV interneurons facilitates their tuning to γ-oscillations.PLoS biology · 2019Article
- Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis.Nature reviews. Neuroscience · 2019Review
- Spontaneous epileptiform activity in a rat model of bilateral subcortical band heterotopia.Epilepsia · 2019Article
- Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders.Frontiers in cell and developmental biology · 2019Review
- Doublecortin Mutation in an Adolescent Male.Child neurology open · 2019Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Disorders of neuronal migration can lead to malformations of the cerebral neocortex that greatly increase the risk of seizures. It remains untested whether malformations caused by disorders in neuronal migration can be reduced by reactivating cellular migration and whether such repair can decrease seizure risk. Here we show, in a rat model of subcortical band heterotopia (SBH) generated by in utero RNA interference of the Dcx gene, that aberrantly positioned neurons can be stimulated to migrate by reexpressing Dcx after birth. Restarting migration in this way both reduces neocortical malformations and restores neuronal patterning. We further find that the capacity to reduce SBH continues into early postnatal development. Moreover, intervention after birth reduces the convulsant-induced seizure threshold to a level similar to that in malformation-free controls. These results suggest that disorders of neuronal migration may be eventually treatable by reengaging developmental programs both to reduce the size of cortical malformations and to reduce seizure risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.