ArticleCell cycle (Georgetown, Tex.)2008
T cell survival and function requires the c-Abl tyrosine kinase.
Article in Cell cycle (Georgetown, Tex.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- The tyrosine kinase c-Abl potentiates interferon-mediated antiviral immunity by STAT1 phosphorylation.iScience · 2021Article
- Kinase inhibitors developed for treatment of hematologic malignancies: implications for immune modulation in COVID-19.Blood advances · 2021Review
- Article
- The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.Journal of cell science · 2016Article
- Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling.Respiratory research · 2015Review
- EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells.Stem cells and development · 2013Article
- Role of Abl in airway hyperresponsiveness and airway remodeling.Respiratory research · 2013Article
- Claudin-1 induces epithelial-mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells.Oncogene · 2013Article
- Article
- Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.Molecular and cellular biology · 2012Article
- c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.Nature cell biology · 2012Article
- Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.Journal of signal transduction · 2012Article
- c-Abl in neurodegenerative disease.Journal of molecular neuroscience : MN · 2011Review
- ABL tyrosine kinases: evolution of function, regulation, and specificity.Science signaling · 2010Review
- Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts.Journal of cell science · 2009Article
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Authors and funding
10 authors.
Funding
Abstract
C-Abl (Abl) regulates multiple cellular processes, including proliferation, survival, shape determination and motility, and participates in cellular responses to genotoxic and oxidative stress stimuli. Mice lacking Abl exhibit retarded growth, osteoporosis and defects in the immune system resulting in lymphopoenia and susceptibility to infections, leading to early death. To define the role of Abl in the regulation of adult T cells we ablated Abl exclusively in T cells by generating mice with floxed abl alleles and expressing an Lck-Cre transgene (Abl-T(-/-)). These mice exhibited thymic atrophy and abnormally reduced T cell numbers in the periphery. The thymic atrophy was caused by increased susceptibility of thymocytes to cell death. Importantly, Abl deficient T cells displayed abnormally reduced response to mitogenic stimulation in vitro. Consequently, Abl-T(-/-) mice exhibited impaired ability to reject syngeneic tumor, to induce T-mediated tumor cell killing, and to generate anti-tumor antibodies. These results demonstrate a cell-autonomous role for Abl in T cell function and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.