Trial reportInvestigative ophthalmology & visual science2009
Predicting visual sensitivity in retinal prosthesis patients.
Trial report in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00279500 (Chronic Retinal Electrodes to Provide Electrical Stimulation of the Retina to Elicit Visual Percepts in Blind Subjects), which is not on this map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Retinal Electrodes to Provide Electrical Stimulation of the Retina to Elicit Visual Percepts in Blind Subjects
Who cites it
42 citing papers in PubMed.
- Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa.Ophthalmology · 2018Trial
- Interim results from the international trial of Second Sight's visual prosthesis.Ophthalmology · 2012Trial
- Frequency and amplitude modulation have different effects on the percepts elicited by retinal stimulation.Investigative ophthalmology & visual science · 2012Trial
- Brightness as a function of current amplitude in human retinal electrical stimulation.Investigative ophthalmology & visual science · 2009Trial
- Fuzzing the brain: automated stress testing for the safety of ML-driven neurostimulation.Journal of neural engineering · 2026Article
- Effect of degeneration stage on non-viral tissue transfection ofMolecular therapy. Nucleic acids · 2025Article
- Simulated prosthetic vision confirms checkerboard as an effective raster pattern for epiretinal implants.Journal of neural engineering · 2025Article
- Evaluating Deep Human-in-the-Loop Optimization for Retinal Implants Using Sighted Participants.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Machine Learning Techniques for Simulating Human Psychophysical Testing of Low-Resolution Phosphene Face Images in Artificial Vision.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Static or Temporal? Semantic Scene Simplification to Aid Wayfinding in Immersive Simulations of Bionic Vision.Proceedings of the ACM Symposium on Virtual Reality Software and Technology. ACM Symposium on Virtual Reality Software and Technology · 2025Article
- A virtual patient simulation modeling the neural and perceptual effects of human visual cortical stimulation, from pulse trains to percepts.Scientific reports · 2024Article
- Predicting the Temporal Dynamics of Prosthetic Vision.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Axonal stimulation affects the linear summation of single-point perception in three Argus II users.Journal of neural engineering · 2024Article
- Axonal stimulation affects the linear summation of single-point perception in three Argus II users.medRxiv : the preprint server for health sciences · 2023Article
- Human-in-the-Loop Optimization for Deep Stimulus Encoding in Visual Prostheses.Advances in neural information processing systems · 2023Article
- Factors affecting two-point discrimination in Argus II patients.Frontiers in neuroscience · 2022Article
- A Computational Model of Phosphene Appearance for Epiretinal Prostheses.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- The impact of synchronous versus asynchronous electrical stimulation in artificial vision.Journal of neural engineering · 2021Review
- Sensitization of ON-bipolar cells with ambient light activatable multi-characteristic opsin rescues vision in mice.Gene therapy · 2021Article
- Harmonization of Outcomes and Vision Endpoints in Vision Restoration Trials: Recommendations from the International HOVER Taskforce.Translational vision science & technology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeWith the long-term goal of restoring functional vision in patients with retinal degenerative diseases, the eyes of blind human subjects were implanted chronically with epiretinal prostheses consisting of two-dimensional electrode arrays that directly stimulated cells of the neural retina.
methodsPsychophysical techniques were used to measure the brightness of electrically generated percepts on single electrodes using a variety of electrical stimulation patterns.
resultsIt was possible to predict the sensitivity of the human visual system to a wide variety of retinal electrical stimulation patterns using a simple and biologically plausible model.
conclusionsThis is the first study to demonstrate that, on the single-electrode level, retinal electrical stimulation in humans can produce visual qualia that are predictable using a quantitative model, a prerequisite for a successful retinal prosthesis. (ClinicalTrials.gov number, NCT00279500.).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.