ArticleJournal of lipid research2009
Dimyristoylphosphotidylcholine induces conformational changes in apoB that lowers lipoprotein(a).
Article in Journal of lipid research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Comparative Evaluation of Three Nucleic Acid-Based Assays for BK Virus Quantification.Journal of clinical microbiology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipoprotein(a) [Lp(a)] is assembled by the binding of apolipoprotein B (apoB) lysine residues on LDL to lysine binding sites in apolipoprotein(a) [apo(a)] and the subsequent formation of a disulphide bond between apoB and apo(a). In this study, we induced changes in apoB conformation by adding phospholipids to LDL and tested the effect of the altered apoB conformation on Lp(a) assembly. The addition of dimyristoylphosphatidylcholine (DMPC) to isolated LDL induced a decrease in the alpha-helical content of apoB and increased the immunoreactivity of the apoB C terminus toward monoclonal antibodies in the region. These conformational changes were associated with a reduction in the ability of the DMPC-modified LDL to form Lp(a) in in vitro assays. Furthermore, administration of DMPC to Lp(a) transgenic mice lead to a significant but transient decrease in Lp(a) levels (18.6% decrease at 2 h, P < 0.001) which coincided with the association of DMPC with LDL in plasma. Our study shows that changes in apoB conformation in the C-terminal region alter the exposure of sequences required for Lp(a) assembly and reduce the formation of Lp(a) both in vitro and in vivo. We conclude that manipulation of LDL surface phospholipids alters Lp(a) levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.