ArticleAmerican journal of physiology. Lung cellular and molecular physiology2009
Myeloid cells control termination of lung inflammation through the NF-kappaB pathway.
Article in American journal of physiology. Lung cellular and molecular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Regulatory functional role of NLRP3 inflammasome during Mycoplasma hyopneumoniae infection in swine.Journal of animal science · 2023Article
- Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis.Molecular cancer research : MCR · 2022Article
- Enhanced Expression of Catalase in Mitochondria Modulates NF-κB-Dependent Lung Inflammation through Alteration of Metabolic Activity in Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Deletion of NFKB1 enhances canonical NF-κB signaling and increases macrophage and myofibroblast content during tendon healing.Scientific reports · 2019Article
- NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.Infection and immunity · 2018Article
- Article
- Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions.International journal of nanomedicine · 2016Article
- Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation.American journal of respiratory cell and molecular biology · 2015Article
- Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Suppression of lung inflammation in an LPS-induced acute lung injury model by the fruit hull of Gleditsia sinensis.BMC complementary and alternative medicine · 2014Article
- Tracking NF-κB activity in tumor cells during ovarian cancer progression in a syngeneic mouse model.Journal of ovarian research · 2013Article
- NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Article
- Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- -449 C>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis.World journal of gastroenterology · 2012Article
- Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis.Carcinogenesis · 2012Article
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- Epithelial cells modulate genes associated with NF kappa B activation in co-cultured human macrophages.Immunobiology · 2011Article
- An NFKB1 promoter insertion/deletion polymorphism influences risk and outcome in acute respiratory distress syndrome among Caucasians.PloS one · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although acute lung inflammation in response to local or systemic infection involves myeloid and nonmyeloid cells, the interplay between different cell types remains poorly defined. Since NF-kappaB is a key transcription factor for innate immunity, we investigated whether dysregulated NF-kappaB activation in myeloid cells impacts inflammatory signaling in nonmyeloid cells and generation of neutrophilic lung inflammation in response to systemic endotoxemia. We generated bone marrow chimeras by fetal liver transplantation of cells deficient in IkappaBalpha or p50 into lethally irradiated NF-kappaB reporter transgenic mice. No differences were apparent between bone marrow chimeras in the absence of an inflammatory stimulus; however, following intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS), IkappaBalpha- or p50-deficient bone marrow chimeras showed increased NF-kappaB activation in nonhematopoietic cells, exaggerated neutrophilic inflammation, and higher mortality compared with untransplanted reporter mice and wild-type bone marrow chimeras. Primary bone marrow-derived macrophages (BMDM) from IkappaBalpha(-/-) or p50(-/-) exhibited increased NF-kappaB activation and macrophage inflammatory protein-2 production after LPS treatment compared with wild-type cells, and coculture of BMDM with lung epithelial (A549) cells resulted in increased NF-kappaB activation in A549 cells and excess IL-8 production by these epithelial cells. These studies indicate an important role for inhibitory members of the NF-kappaB family acting specifically within myeloid cells to limit inflammatory responses in the lungs.
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