ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Altered senescence and mitochondrial transcriptome defines age-related changes in satellite cells.Frontiers in cell and developmental biology · 2025Article
- Single-cell chromatin accessibility profiling reveals a self-renewing muscle satellite cell state.The Journal of cell biology · 2023Article
- An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs.The EMBO journal · 2022Article
- Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood.Scientific reports · 2020Article
- Article
- Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq.eLife · 2019Article
- The Danger Signal Extracellular ATP Is Involved in the Immunomediated Damage of α-Sarcoglycan-Deficient Muscular Dystrophy.The American journal of pathology · 2019Article
- IL-15 promotes human myogenesis and mitigates the detrimental effects of TNFα on myotube development.Scientific reports · 2017Article
- Myogenic progenitors and imaging single-cell flow analysis: a model to study commitment of adult muscle stem cells.Journal of muscle research and cell motility · 2014Article
- Differentiation of human skeletal muscle stem cells into odontoblasts is dependent on induction of α1 integrin expression.The Journal of biological chemistry · 2014Article
- Matrix metalloproteinase inhibition negatively affects muscle stem cell behavior.International journal of clinical and experimental pathology · 2013Article
- Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: application to a cohort of power lifters and sedentary men.Histochemistry and cell biology · 2010Article
- Differentiation and sarcomere formation in skeletal myocytes directly prepared from human induced pluripotent stem cells using a sphere-based culture.Differentiation; research in biological diversityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Studies using mouse models have established a critical role for resident satellite stem cells in skeletal muscle development and regeneration, but little is known about this paradigm in human muscle. Here, using human muscle stem cells, we address their lineage progression, differentiation, migration, and self-renewal. Isolated human satellite cells expressed alpha7-integrin and other definitive muscle markers, were highly motile on laminin substrates and could undergo efficient myotube differentiation and myofibrillogenesis. However, only a subpopulation of the myoblasts expressed Pax7 and displayed a variable lineage progression as measured by desmin and MyoD expression. Analysis identified a differentiation-resistant progenitor cell population that was Pax7+/desmin- and capable of self-renewal. This study extends our understanding of the role of Pax7 in regulating human satellite stem cell differentiation and self-renewal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.