ArticlePathology oncology research : POR2009
Presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) in ameloblastomas correlate with rupture of the osseous cortical.
Article in Pathology oncology research : POR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Comparison of Myofibroblasts Between Solid/Multicystic Ameloblastoma and Unicystic Ameloblastoma: An Immunohistochemical Analysis.Journal of clinical and diagnostic research : JCDR · 2016Article
- Immunohistochemical evaluation of myofibroblast density in odontogenic cysts and tumors.Journal of dental research, dental clinics, dental prospects · 2016Article
- EGFR signaling downstream of EGF regulates migration, invasion, and MMP secretion of immortalized cells derived from human ameloblastoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Myofibroblasts in oral lesions: A review.Journal of oral and maxillofacial pathology : JOMFP · 2014Review
- Molecular markers of tumor invasiveness in ameloblastoma: An update.Annals of maxillofacial surgery · 2011Article
- Immunohistochemical Expression of Myofibroblasts Using Alpha-smooth Muscle Actin (SMA) to Assess the Aggressive Potential of Various Clinical Subtypes of Ameloblastoma.Journal of microscopy and ultrastructureArticle
- Immunohistochemical and clinical significance of matrix metalloproteinase-2 and its inhibitor in oral lichen planus.Journal of oral and maxillofacial pathology : JOMFPArticle
- Immunohistochemical study of alpha-smooth muscle actin in odontogenic cysts and tumors.Journal of oral and maxillofacial pathology : JOMFPArticle
- Myofibroblasts in Odontogenic Cysts and Tumors: An Immunohistochemical Study.Journal of microscopy and ultrastructureArticle
- Molecular and genetic aspects in the etiopathogenesis of ameloblastoma: An update.Journal of oral and maxillofacial pathology : JOMFPReview
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
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Abstract
Myofibroblasts are frequent in the stroma of neoplasm and by the expression of proteinases they can influence tumor infiltration and progression. In the present study, presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) and urokinase plasminogen activator (uPA) were examined in intra-osseous solid multicystic ameloblastomas to determine their roles in the clinicopathological features of the tumors. Fifty seven ameloblastomas were analyzed immunohistochemically with antibodies against the isoform alpha of the smooth muscle actin (alpha-SMA), a specific marker of myofibroblasts, MMP-2 and uPA. Myofibroblasts were found in the stroma, in close contact with neoplastic cell islands, of approximately 58% (n = 33) of the ameloblastomas. MMP-2 and uPA were found in the cytoplasm of both neoplastic and stromal cells. A significant correlation between presence of myofibroblasts and MMP-2 expression was observed. Abundant presence of myofibroblast in the stroma of the tumors and expression of MMP-2 in the neoplastic or stromal cells were significantly correlated with rupture of the osseous cortical, which has been considered an important prognostic marker of ameloblastoma aggressiveness. Ours results suggest that abundant presence of myofibroblasts and expression of MMP-2 in solid ameloblastomas may be associated with a more aggressive infiltrative behavior.
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