ArticleEuropean journal of nuclear medicine and molecular imaging2009
Comparison of subcutaneous and intraperitoneal injection of D-luciferin for in vivo bioluminescence imaging.
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- A practical guideline for in vivo bioluminescence imaging.Molecules and cells · 2026Review
- Lidocaine Enhanced Antitumor Efficacy and Relieved Chemotherapy-Induced Hyperalgesia in Mice with Metastatic Gastric Cancer.International journal of molecular sciences · 2025Article
- Bioluminescent Imaging of Patient-Derived Brain Tumors in Live Mice.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Bioluminescent Systems for Theranostic Applications.International journal of molecular sciences · 2024Review
- Method of long-term, recurrent, intracerebroventricular infusion of cellular therapy in mice.Journal of neuroscience methods · 2022Article
- A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo.Science signaling · 2022Article
- Advanced Bioluminescence System for In Vivo Imaging with Brighter and Red-Shifted Light Emission.International journal of molecular sciences · 2020Review
- Real-time tracking of stem cell viability, proliferation, and differentiation with autonomous bioluminescence imaging.BMC biology · 2020Article
- Kinetic modeling and analysis of dynamic bioluminescence imaging of substrates administered by intraperitoneal injection.Quantitative imaging in medicine and surgery · 2020Article
- Continuous and Real-Time In Vivo Autobioluminescent Imaging in a Mouse Model.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Quantitative assessment of human uterine fibroid xenograft using sequential in vivo bioluminescence imaging.American journal of translational research · 2019Article
- Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720.PloS one · 2019Article
- A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions.Journal of medicinal chemistry · 2018Article
- Use of luciferase probes to measure ATP in living cells and animals.Nature protocols · 2017Article
- Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity.International journal of molecular sciences · 2017Article
- Bioluminescence and MR Imaging of the Safety and Efficacy of Vascular Disruption in Gliomas.Molecular imaging and biology · 2016Article
- The effects of dosage and the routes of administrations of streptozotocin and alloxan on induction rate of type1 diabetes mellitus and mortality rate in rats.Laboratory animal research · 2016Article
- A Multimodal Imaging Approach for Longitudinal Evaluation of Bladder Tumor Development in an Orthotopic Murine Model.PloS one · 2016Article
- Non-invasive imaging of implanted peritoneal carcinomatosis in mice using PET and bioluminescence imaging.EJNMMI research · 2015Article
- Dynamic bioluminescence and fluorescence imaging of the effects of the antivascular agent Combretastatin-A4P (CA4P) on brain tumor xenografts.Cancer letters · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
purposeWe compared subcutaneous (SC) injection and intraperitoneal (IP) injection of D-luciferin for in vivo bioluminescence imaging (BLI) to determine the utility of SC injection.
methodsMice bearing SC tumours stably expressing firefly luciferase underwent in vivo BLI using SC and IP injection of D: -luciferin. BLI studies were repeated at an interval of 3 h using a given injection route to assess repeatability and using different injection routes to assess correlation. In mice bearing both SC and IP tumours, BLI was performed successively using intravenous (IV), SC, and IP injection of D: -luciferin. Haematological malignancy model mice underwent BLI using SC and IP injection.
resultsIn SC tumours, the peak time was slightly shorter and the peak signal was greater using SC injection than using IP injection. The repeatability of determining peak signals was comparable between the two injection routes, and a good correlation was observed between them. In mice bearing both SC and IP tumours, signals from IP tumours relative to those from SC tumours were much greater using IP injection than using IV or SC injection. In the haematological malignancy model, signals from the spleen relative to those from the bone marrow were greater using IP injection than using SC injection.
conclusionIn addition to rare injection failure, the IP injection of D: -luciferin led to the overestimation of signals from IP tissues. For BLI, SC injection was shown to be a convenient alternative to IP injection.
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