ArticleDiabetologia2009
Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain.
Article in Diabetologia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 53 citations in OpenAlex.
- Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort.Diabetologia · 2011Trial
- Measures of Brain Metabolism and Diffusion in Neonates of Mothers with Diabetes.AJNR. American journal of neuroradiology · 2026Article
- Change in medial frontal cerebral metabolite concentrations following bariatric surgery.NMR in biomedicine · 2023Article
- Atrophy of the optic chiasm is associated with microvascular diabetic complications in type 1 diabetes.Frontiers in endocrinology · 2023Article
- Hyperglycemia and hyperinsulinemia effects on anterior cingulate cortex myoinositol-relation to brain network functional connectivity in healthy adults.Journal of neurophysiology · 2022Article
- Potential for Ketotherapies as Amyloid-Regulating Treatment in Individuals at Risk for Alzheimer's Disease.Frontiers in neuroscience · 2022Review
- Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects theInternational journal of molecular sciences · 2020Article
- Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2020Article
- The neurometabolic profiles of GABA and Glutamate as revealed by proton magnetic resonance spectroscopy in type 1 and type 2 diabetes.PloS one · 2020Article
- Elevated brain glutamate levels in type 1 diabetes: correlations with glycaemic control and age of disease onset but not with hypoglycaemia awareness status.Diabetologia · 2019Article
- Altered brain metabolites in patients with diabetes mellitus and related complications - evidence fromBioscience reports · 2018Review
- Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Alteration of interaction between astrocytes and neurons in different stages of diabetes: a nuclear magnetic resonance study using [1-(13)C]glucose and [2-(13)C]acetate.Molecular neurobiology · 2015Article
- Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes mellitus.Metabolism: clinical and experimental · 2014Article
- Astrocytic and microglial response in experimentally induced diabetic rat brain.Metabolic brain disease · 2014Article
- Neurochemical profile of patients with type 1 diabetes measured by ¹H-MRS at 4 T.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Cognitive impairment in diabetic patients: Can diabetic control prevent cognitive decline?Journal of diabetes investigation · 2012Review
- Cognition and Hemodynamics.Current cardiovascular risk reports · 2012Article
- Steady-state brain glucose concentrations during hypoglycemia in healthy humans and patients with type 1 diabetes.Diabetes · 2012Article
- Effects of duration of diabetes on behavioural and cognitive parameters in streptozotocin-induced juvenile diabetic rats.The Malaysian journal of medical sciences : MJMS · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of the study was to assess the effect of hyperglycaemia on regional concentrations of glucose and other substrates within the brain in non-diabetic individuals and in patients with type 1 diabetes.
methodsThe brain metabolites of 17 men with type 1 diabetes and 12 age-matched non-diabetic men (22-43 years old) were studied after an overnight fast (plasma glucose 9.2 +/- 3.0 vs 4.8 +/- 0.5 mmol/l, respectively). N-Acetylaspartate (NAA), creatine, choline, myo-inositol (mI) and glucose in the frontal cortex, frontal white matter and thalamus were quantified with proton magnetic resonance spectroscopy.
resultsIn the non-diabetic participants, the glucose level was 47% higher (p < 0.01) in the frontal cortex than in the frontal white matter. In contrast, this regional variation was not observed in the diabetic participants, in whom the glucose level in the frontal white matter was 64% higher (p < 0.001) and in the frontal cortex 25% higher (p = 0.033) than that of the non-diabetic participants. In the diabetic participants, the glucose level in each of the three regions studied correlated with fasting plasma glucose (r = 0.88-0.67, p < 0.01). In addition, in the diabetic participants, mI was 20% higher (p < 0.001) and NAA 6% lower (p = 0.037) in the frontal white matter, and mI was 8% higher (p = 0.042) in the frontal cortex, than in the non-diabetic participants. CONCLUSIONS/
interpretationIn type 1 diabetes, hyperglycaemia is associated with accumulation of glucose and mI in the cortex and in the white matter.
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