ArticleCellular & molecular biology letters2009
Acheron, an novel LA antigen family member, binds to CASK and forms a complex with Id transcription factors.
Article in Cellular & molecular biology letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genome-wide investigation of the LARP gene family: focus on functional identification and transcriptome profiling of ZmLARP6c1 in maize pollen.BMC plant biology · 2024Article
- LARP6C orchestrates posttranscriptional reprogramming of gene expression during hydration to promote pollen tube guidance.The Plant cell · 2021Article
- LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.RNA biology · 2021Review
- The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1.RNA biology · 2021Article
- Maternal Larp6 controls oocyte development, chorion formation and elevation.Development (Cambridge, England) · 2020Article
- Acheron/Larp6 Is a Survival Protein That Protects Skeletal Muscle From Programmed Cell Death During Development.Frontiers in cell and developmental biology · 2020Article
- The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.Wiley interdisciplinary reviews. RNA · 2017Review
- The La-Related Proteins, a Family with Connections to Cancer.Biomolecules · 2015Review
- LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.RNA (New York, N.Y.) · 2015Article
- Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.Nucleic acids research · 2015Article
- Hypoxia-induced alternative splicing in endothelial cells.PloS one · 2012Article
- A stimulatory role for the La-related protein 4B in translation.RNA (New York, N.Y.) · 2010Article
- Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts.American journal of physiology. Cell physiology · 2010Article
- Conserved and divergent features of the structure and function of La and La-related proteins (LARPs).Biochimica et biophysica actaReview
Corrections and comments
- Erratum issuedErratum: Acheron, an novel LA antigen family member, binds to cask and forms a complex with id transcription factors.2009 · Dosage error in article text
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acheron, a Lupus antigen ortholog, was identified as a novel death-associated transcript from the intersegmental muscles of the moth Manduca sexta. Acheron is phylogenetically-conserved and represents a new sub-family of Lupus antigen proteins. Acheron is expressed predominantly in neurons and muscle in vertebrates, and regulates several developmental events including myogenesis, neurogenesis and possibly metastasis. Using Acheron as bait, we performed a yeast two-hybrid screen with a mouse embryo cDNA library and identified CASK-C, a novel CASK/Lin-2 isoform, as an Acheron binding partner. Acheron and CASK-C bind via the C-terminus of Acheron and the CaMKII-like domain of CASK-C. Co-immunoprecipitation assays verify this interaction and demonstrate that Acheron also forms a complex with all members of the Id (inhibitor of differentiation) proteins. Taken together, these data suggest a mechanism by which Acheron may regulate development and pathology.
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Registered trials
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