ArticlePLoS genetics2008
Developmental constraints on vertebrate genome evolution.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 114 citations in OpenAlex.
- Article
- Internalized Evolutionary Inertia on Body Plan Evolution.Evolution & development · 2026Review
- A transcriptomic hourglass in brown algae.Nature · 2024Article
- Article
- The developmental hourglass model and recapitulation: An attempt to integrate the two models.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NADScience China. Life sciences · 2021Article
- Evolution and genomic organization of the insect sHSP gene cluster and coordinate regulation in phenotypic plasticity.BMC ecology and evolution · 2021Article
- Cancer progression as a sequence of atavistic reversions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Article
- Speciation and the developmental alarm clock.eLife · 2020Review
- Evolutionary trends of the conserved neurocranium shape in angel sharks (Squatiniformes, Elasmobranchii).Scientific reports · 2020Article
- Article
- Molecular evolution across developmental time reveals rapid divergence in early embryogenesis.Evolution letters · 2019Article
- Gene expression across mammalian organ development.Nature · 2019Article
- Adaptation and Conservation throughout the Drosophila melanogaster Life-Cycle.Genome biology and evolution · 2019Article
- The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns.Scientific reports · 2019Article
- Adaptive Evolution of Animal Proteins over Development: Support for the Darwin Selection Opportunity Hypothesis of Evo-Devo.Molecular biology and evolution · 2018Article
- Developmental Constraints on Genome Evolution in Four Bilaterian Model Species.Genome biology and evolution · 2018Article
- Article
- Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos.EvoDevo · 2018Article
- Selective Constraints on Coding Sequences of Nervous System Genes Are a Major Determinant of Duplicate Gene Retention in Vertebrates.Molecular biology and evolution · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Constraints in embryonic development are thought to bias the direction of evolution by making some changes less likely, and others more likely, depending on their consequences on ontogeny. Here, we characterize the constraints acting on genome evolution in vertebrates. We used gene expression data from two vertebrates: zebrafish, using a microarray experiment spanning 14 stages of development, and mouse, using EST counts for 26 stages of development. We show that, in both species, genes expressed early in development (1) have a more dramatic effect of knock-out or mutation and (2) are more likely to revert to single copy after whole genome duplication, relative to genes expressed late. This supports high constraints on early stages of vertebrate development, making them less open to innovations (gene gain or gene loss). Results are robust to different sources of data -- gene expression from microarrays, ESTs, or in situ hybridizations; and mutants from directed KO, transgenic insertions, point mutations, or morpholinos. We determine the pattern of these constraints, which differs from the model used to describe vertebrate morphological conservation ("hourglass" model). While morphological constraints reach a maximum at mid-development (the "phylotypic" stage), genomic constraints appear to decrease in a monotonous manner over developmental time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.