ArticleMolecular systems biology2008
Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system.
Article in Molecular systems biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Mimicking blood and lymphatic vasculatures using microfluidic systems.Biomicrofluidics · 2024Review
- Portable dielectrophoresis for biology: ADEPT facilitates cell trapping, separation, and interactions.Microsystems & nanoengineering · 2024Article
- Cell pairing for biological analysis in microfluidic devices.Biomicrofluidics · 2022Review
- Roles of Remote and Contact Forces in Epithelial Cell Structure Formation.Biophysical journal · 2020Article
- Bridging the gap: microfluidic devices for short and long distance cell-cell communication.Lab on a chip · 2017Review
- Microfluidic device for primary tumor spheroid isolation.Experimental hematology & oncology · 2017Article
- Precisely parameterized experimental and computational models of tissue organization.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Automated profiling of individual cell-cell interactions from high-throughput time-lapse imaging microscopy in nanowell grids (TIMING).Bioinformatics (Oxford, England) · 2015Article
- Standing surface acoustic wave based cell coculture.Analytical chemistry · 2014Article
- Probing cell-cell communication with microfluidic devices.Lab on a chip · 2013Review
- A cell-based model of extracellular-matrix-guided endothelial cell migration during angiogenesis.Bulletin of mathematical biology · 2013Article
- Synthetic spatially graded Rac activation drives cell polarization and movement.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Heterotypic cell pair co-culturing on patterned microarrays.Lab on a chip · 2012Article
- Integration of experimental and computational approaches to sprouting angiogenesis.Current opinion in hematology · 2012Review
- Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction.Cancer research · 2011Article
- Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments.Biomicrofluidics · 2011Article
- An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments.Integrative biology : quantitative biosciences from nano to macro · 2010Article
- Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires.Nature nanotechnology · 2010Article
- Models at the single cell level.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood vessel formation, during either normal vascular reconstruction or pathogenic tumour formation, relies upon highly organized cell-cell interactions. Isolating the function of any particular component of this cell-cell communication is often difficult, given the vast complexity of communication networks in multicellular systems. One way to address this problem is to analyse cell-cell communication on the most elementary scale--cell pairs. Here, we describe an integrated dielectrophoretic (DEP)-microfluidic device allowing for such analysis. Single cancer and endothelial cells (ECs) and cell pairs were patterned using DEP force and cultured within a minimally stressful microfluidic channel network. Controlling both the initial cell positions and extracellular environment, we investigated cell motility in homo- and heterotypic cell pairs under diverse conditions. We found that secreted collagen IV and soluble vascular endothelial growth factor have considerable guidance effect on ECs at the level of two interacting cells. Cell interaction rules extracted from the experiments of cell pairs were used to mathematically predict branching patterns characteristic of developing multicellular blood vessels. This integrative analysis method can be extended to other systems involving complex multicellular interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.