Evidence map›Paper›PMID 19096164›Full record

ReviewJournal of Alzheimer's disease : JAD2008

Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle.

Othman Ghribi

RetractedOpen access · greenAbstract readReviewRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 66 citations in OpenAlex.

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  16. Apolipoprotein E ε-4 as a genetic determinant of Alzheimer's disease heterogeneity.Degenerative neurological and neuromuscular disease · 2015
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Othman GhribiDepartment of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, ND 58202, USA. oghribi@medicine.nodak.edu
University of North Dakota · US

Funding

TRPC1, CALCIUM AND PARKINSON'S DISEASEP20RR017699 · NCRR · UNIVERSITY OF NORTH DAKOTA · PI GROVE, BRYON D · 2002 to 2011
$19.7M
Cholesterol induces oxidative stress and triggers iron and A? accumulationR01ES014826 · NIEHS · UNIVERSITY OF NORTH DAKOTA · PI GHRIBI, OTHMAN · 2008 to 2012
$1.5M
NCRR NIH HHS 5P20RR017699NCRR NIH HHS P20 RR017699NIEHS NIH HHS R01 ES014826NIEHS NIH HHS R01ES014826
6 · The paper itself

Abstract

Epidemiological, animal, and cellular studies suggest that abnormalities in cholesterol metabolism are important in the pathogenesis of Alzheimer's disease (AD), potentially by increasing amyloid-beta (Abeta) peptide levels. Accumulation of Abeta in the brain is suggested to play a key role in the neurodegenerative processes by triggering the hyperphosphorylation of tau and the neuronal death that develop in the course of AD. However, the mechanisms by which cholesterol increases Abeta levels are still ill-defined. Previous and ongoing work from our laboratory indicates that hypercholesterolemia leads to the increased neuronal content of cholesterol and increased levels and processing of the amyloid-beta protein precursor (AbetaPP). We also have found that the oxidized cholesterol metabolite, 27-hydroxycholesterol, increases Abeta levels in both organotypic hippocampal slices and in neuronal preparations cultured from adult rabbits. This cholesterol metabolite is predominantly formed in the circulation and, in contrast to cholesterol, has the ability to cross into the brain. These results may indicate that 27-hydroxycholesterol is the link between circulating cholesterol and AD-like pathology in the brain. We also have found pathological hallmarks in the skeletal muscle of cholesterol-fed rabbits that are suggestive of inclusion body myositis, a disease that shares some pathological similarities with AD.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainBrain ChemistryCholesterolHippocampusHumansHydroxycholesterolsMuscle, SkeletalMyositis, Inclusion BodyOrgan Culture TechniquesRabbitstau Proteins27-hydroxycholesterolAmyloid beta-PeptidesCholesterolHydroxycholesterolstau Proteins

Identifiers

PMID19096164
PMCPMC2805037
OpenAlexW1521675224

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.