Trial reportNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2009
A clinical score to predict 6-month prognosis in elderly patients starting dialysis for end-stage renal disease.
Trial report in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02910908 (Characteristics and Treatment Course of Patients Older Than 75 Years Old Reaching ESRD. Development of a Prognosis Tools for Early Mortality), which is not on this map. Cited by 107 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characteristics and Treatment Course of Patients Older Than 75 Years Old Reaching ESRD. Development of a Prognosis Tools for Early Mortality
Who cites it
107 citing papers in PubMed, 6 syntheses or guidelines pooled it, 320 citations in OpenAlex.
- Mortality Risk Prediction Models for People With Kidney Failure: A Systematic Review.JAMA network open · 2025Pooled it
- Age, Gender and Diabetes as Risk Factors for Early Mortality in Dialysis Patients: A Systematic Review.Clinical medicine & research · 2021Pooled it
- Functional and Cognitive Impairment, Frailty, and Adverse Health Outcomes in Older Patients Reaching ESRD-A Systematic Review.Clinical journal of the American Society of Nephrology : CJASN · 2016Pooled it
- The Relevance of Geriatric Impairments in Patients Starting Dialysis: A Systematic Review.Clinical journal of the American Society of Nephrology : CJASN · 2016Pooled it
- Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: developing a roadmap to improving quality care.Kidney international · 2015Guideline
- Conservative management of end-stage renal disease without dialysis: a systematic review.Journal of palliative medicine · 2012Pooled it
- Quality of life as indicator of poor outcome in hemodialysis: relation with mortality in different age groups.BMC nephrology · 2017Trial
- Survival prognosis after the start of a renal replacement therapy in the Netherlands: a retrospective cohort study.BMC nephrology · 2013Trial
- Walking autonomy in chronic dialysis patients: insights from a nationwide registry and focus group analysis.Clinical kidney journal · 2025Article
- Geriatric Assessment in Older Patients with Advanced Kidney Disease: A Key to Personalized Care and Shared Decision-Making-A Narrative Review.Journal of clinical medicine · 2025Review
- Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients.Renal failure · 2024Article
- Predicting early mortality in hemodialysis patients: a deep learning approach using a nationwide prospective cohort in South Korea.Scientific reports · 2024Article
- Article
- Article
- Prognostication After Dialysis Withdrawal.Kidney international reports · 2024Article
- External validation of the 2-year mortality prediction tool in hemodialysis patients developed using a Bayesian network.Clinical kidney journal · 2024Article
- Short-term and long-term survival in patients with prevalent haemodialysis-an integrated prognostic model: external validation.BMJ supportive & palliative care · 2024Article
- Review
- The Lack of a Standardized Definition of Chronic Dialysis Treatment in German Statutory Health Insurance Claims Data—Effects on Estimated Incidence and Mortality.Deutsches Arzteblatt international · 2024Observational
- The error of estimated GFR in predialysis care.Scientific reports · 2024Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to develop and validate a prognostic score for 6-month mortality in elderly patients starting dialysis for end-stage renal disease.
methodsUsing data from the French Rein registry, we developed a prognostic score in a training sample of 2500 patients aged 75 years or older who started dialysis between 2002 and 2006, which we validated in a similar sample of 1642 patients. Multivariate logistic regression with 500 bootstrap samples allowed us to select risk factors from 19 demographic and baseline clinical variables.
resultsThe overall 6-month mortality was 19%. Age was not associated with early mortality. Nine risk factors were selected and points assigned for the score were as follows: body mass index <18.5 kg/m2 (2 points), diabetes (1), congestive heart failure stages III to IV (2), peripheral vascular disease stages III to IV (2), dysrhythmia (1), active malignancy (1), severe behavioural disorder (2), total dependency for transfers (3) and unplanned dialysis (2). The median score was 2. Mortality rates ranged from 8% in the lowest risk group (0 point) to 70% in the highest risk group (> or =9 points) and 17% in the median group (2 points). Seventeen percent of all deaths occurred after withdrawal from dialysis, ranging from 0% for a score of 0-1 to 15% for a score of 7 or higher.
conclusionsThis simple clinical score effectively predicts short-term prognosis among elderly patients starting dialysis. It should help to illuminate clinical decision making, but cannot be used to withhold dialysis. It ought to only be used by nephrologists to facilitate the discussion with the patients and their families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.