ArticleProceedings of the National Academy of Sciences of the United States of America2008
Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Imaging intercellular biomolecules by using fluorescent protein indicators with lipid-PEG anchors.Scientific reports · 2026Article
- Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model.Acta pharmacologica Sinica · 2025Article
- A molecular switch in RCK2 triggers sodium-dependent activation of KBiophysical journal · 2024Article
- Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons.Cell reports · 2024Article
- Coupling of Slack and NaeLife · 2024Article
- Slack KCommunications biology · 2023Article
- The NaCellular and molecular life sciences : CMLS · 2021Article
- A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats.Neuroscience bulletin · 2021Article
- Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing.International journal of molecular sciences · 2021Article
- Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KiScience · 2020Article
- An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Identification of potential novel interaction partners of the sodium-activated potassium channels Slick and Slack in mouse brain.Biochemistry and biophysics reports · 2015Article
- The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Dynamic dendritic compartmentalization underlies stimulus-specific adaptation in an insect neuron.Journal of neurophysiology · 2015Article
- SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans.Nature communications · 2014Article
- Neuronal adaptation, novelty detection and regularity encoding in audition.Frontiers in systems neuroscience · 2014Article
- TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.Nature neuroscience · 2013Article
- Differential regulation of synaptic transmission by pre- and postsynaptic SK channels in the spinal locomotor network.Journal of neurophysiology · 2013Article
- Slack, Slick and Sodium-Activated Potassium Channels.ISRN neuroscience · 2013Article
- Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Na(+)-activated K(+) (K(Na)) channels are expressed in neurons and are activated by Na(+) influx through voltage-dependent channels or ionotropic receptors, yet their function remains unclear. Here we show that K(Na) channels are associated with AMPA receptors and that their activation depresses synaptic responses. Synaptic activation of K(Na) channels by Na(+) transients via AMPA receptors shapes the decay of AMPA-mediated current as well as the amplitude of the synaptic potential. Thus, the coupling between K(Na) channels and AMPA receptors by synaptically induced Na(+) transients represents an inherent negative feedback mechanism that scales down the magnitude of excitatory synaptic responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.