ArticleClinical chemistry2009
Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.
Article in Clinical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 47 citations in OpenAlex.
- Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome.Biomedical reports · 2024Article
- Serum uric acid and high-sensitivity C-reactive protein levels among people living with HIV on dolutegravir and ritonavir-boosted atazanavir-based antiretroviral therapy: a comparative cross-sectional study.Frontiers in medicine · 2024Article
- Association of high-sensitivity C-reactive protein and diabetic nephropathy in patients with type 2 diabetes: a Mendelian randomization study.BMJ open diabetes research & care · 2023Observational
- C-reactive protein in adult Samoans: Population variation and physiological correlates.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women.Women's midlife health · 2020Article
- Plasma C-Reactive Protein and Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis.Chinese medical journal · 2018Article
- CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study.Scientific reports · 2017Article
- C-Reactive Protein Gene Contributes to the Genetic Susceptibility of Hemorrhagic Stroke in Men: a Case-Control Study in Chinese Han Population.Journal of molecular neuroscience : MN · 2017Article
- Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma.The American journal of psychiatry · 2015Article
- C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes.BMC endocrine disorders · 2015Article
- A Bayesian approach for instrumental variable analysis with censored time-to-event outcome.Statistics in medicine · 2015Article
- C-reactive protein gene variants: independent association with late-life depression and circulating protein levels.Translational psychiatry · 2015Article
- HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population.PloS one · 2014Article
- Association study of CRP gene and ischemic stroke in a Chinese Han population.Journal of molecular neuroscience : MN · 2013Article
- Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population.PloS one · 2013Article
- A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women.Diabetes · 2012Article
- C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.Human molecular genetics · 2012Article
- C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort.Journal of human hypertension · 2012Article
- CRP gene variation affects early development of Alzheimer's disease-related plaques.Journal of neuroinflammation · 2011Article
- Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival.International journal of cancer · 2011Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAlthough common genetic variants of the CRP gene (C-reactive protein, pentraxin related) have been associated with plasma concentrations of high-sensitivity CRP (hsCRP) in several cohorts of European Americans, relatively few studies have comprehensively assessed this association in well-characterized multiethnic populations.
methodsIn a case-control study of diabetes nested in the Women's Health Initiative Observational Cohort, we comprehensively evaluated the association of genetic variation in CRP with plasma hsCRP concentrations. Thirteen haplotype-tagging single-nucleotide polymorphisms (tSNPs) were identified and subsequently genotyped in 3782 postmenopausal women.
resultsThe allele frequencies for these tSNPs and the haplotype blocks defined by these tSNPs varied significantly by ethnic group (P < 0.0001). Consistent with prior studies of whites, rs3093068, rs1130864, and rs1417938 were significantly associated with higher hsCRP concentrations (geometric-mean increase per minor-allele change, 1.20-1.25 mg/L), and rs1205 and rs1800947 were significantly associated with lower hsCRP values (decrease of 1.28-1.48 mg/L). The associations with rs3093068 and rs1205 appeared to be stronger in Asians/Pacific Islanders than in whites (geometric-mean increase, 1.65 mg/L vs 1.25 mg/L, respectively). Minor alleles at rs3093075 and rs3093059 were associated with substantially increased hsCRP concentrations, whereas rs1800947 was associated with lower hsCRP values. All haplotype-based association results tended to be consistent with the associations seen with single CRP SNPs.
conclusionsOur large multiethnic case-control study of postmenopausal women provides evidence that common genetic variants in the CRP gene are substantially associated with plasma hsCRP concentrations in this case-control subcohort. The data also suggest ethnic variations in these associations.
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