ArticleNeuroImage2009
Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging.
Article in NeuroImage, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Long-term clinical outcomes of delirium after hospital discharge: a systematic review and meta-analysis.Age and ageing · 2025Pooled it
- APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume.Kidney international · 2016Pooled it
- Association between pregabalin use and delirium in critically ill patients aged 60 and older: a retrospective analysis of the MIMIC-IV database.Open medicine (Warsaw, Poland) · 2026Article
- 3DCNN predicting brain age using diffusion tensor imaging.Medical & biological engineering & computing · 2023Article
- Elderly Patients and Management in Intensive Care Units (ICU): Clinical Challenges.Clinical interventions in aging · 2023Review
- Regional glucose metabolic decreases with ageing are associated with microstructural white matter changes: a simultaneous PET/MR study.European journal of nuclear medicine and molecular imaging · 2022Article
- Liver diseases as a novel risk factor for delirium in the ICU-Delirium and hepatic encephalopathy are two distinct entities.PloS one · 2022Observational
- Why is delirium more frequent in the elderly?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- 3T MRI Whole-Brain Microscopy Discrimination of Subcortical Anatomy, Part 2: Basal Forebrain.AJNR. American journal of neuroradiology · 2019Article
- Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.Molecular neurobiology · 2019Article
- Objective PET study of glucose metabolism asymmetries in children with epilepsy: Implications for normal brain development.Human brain mapping · 2019Article
- APOE genotype modifies the association between central arterial stiffening and cognition in older adults.Neurobiology of aging · 2018Article
- Cortical Proprioceptive Processing Is Altered by Aging.Frontiers in aging neuroscience · 2018Article
- Adaptation of the Pharmacological Management of Delirium in ICU Patients in Iran: Introduction and Definition.Iranian journal of psychiatry · 2018Review
- White matter deficits in schizophrenia are global and don't progress with age.The Australian and New Zealand journal of psychiatry · 2017Article
- Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction.European journal of nuclear medicine and molecular imaging · 2017Article
- Pair bond formation leads to a sustained increase in global cerebral glucose metabolism in monogamous male titi monkeys (Callicebus cupreus).Neuroscience · 2017Article
- Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions.Current nutrition reports · 2017Article
- Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging.NeuroImage · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Relationships between structural MRI-based markers of declining cerebral integrity, and regional PET measurements of (18)FDG uptake have not been studied well in normal aging. In this manuscript we relate changes in cerebral morphology to regional cerebral glucose uptake for 14 major cortical areas in 19 healthy older individuals (age 59-92 years). Measurements of cerebral integrity included gray matter (GM) thickness, sulcal and intergyral spans, fractional anisotropy (FA) of water diffusion and volume of hyperintense WM (HWM) lesions. (18)FDG-PET measurements were converted to standard uptake values and corrected for partial volume artifact. Following this, cortical FDG uptake was significantly correlated with several indices of WM integrity that we previously observed to be sensitive to cognitive decline in executive function, including intergyral span and HWM volumes. Our findings suggest that the age-related decline in white matter integrity, observed as increases in HWM lesions, intergyral spans and reduction in FA, correlated with a decline in the global and regional cerebral glucose uptake. Our findings support the emerging consensus that WM integrity indices are sensitive predictors of declining cerebral health in normal aging. Specifically, age-related WM degradation in the thinly myelinated association tracts appears to track the decreases in global and regional rates of glucose uptake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.