ArticleBrain research2009
Effects of osmolality on PLP-null myelin structure: implications re axon damage.
Article in Brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- GeneWalk identifies relevant gene functions for a biological context using network representation learning.Genome biology · 2021Article
- Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis.Chemical reviews · 2019Article
- Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties.Biophysical journal · 2015Article
- Myelin architecture: zippering membranes tightly together.Cellular and molecular life sciences : CMLS · 2014Review
- Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction.Lipids in health and disease · 2011Article
- Claudin Proteins And Neuronal Function.Current topics in membranes · 2010Article
- Sodium channelopathy induced by mild axonal trauma worsens outcome after a repeat injury.Journal of neuroscience research · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In order to test the adhesiveness of PLP-null compact myelin lamellae we soaked aldehyde-fixed CNS specimens from PLP-null and control mice overnight in distilled water, in Ringer's solution or in Ringer's solution with added 1 M sucrose. Subsequent examination of the tissue by EM showed that both PLP-null and control white matter soaked in Ringer remained largely compact. After the distilled water soak, control myelin was virtually unchanged, but PLP-null myelin showed some decompaction, i.e., separation of myelin lamellae from one another. After the sucrose/Ringer soak, normal myelin developed foci of decompaction, but the great majority of lamellae remained compact. In the PLP-null specimens, in contrast, many of the myelin sheaths became almost completely decompacted. Such sheaths became thicker overall and were comprised of lamellae widely separated from one another by irregular spaces. Thus, in normal animals, fixed CNS myelin lamellae are firmly adherent and resist separation; PLP-null myelin lamellae, in contrast, are poorly adherent and more readily separated. Mechanisms by which impaired adhesiveness of PLP-null myelin lamellae and fluctuations in osmolality in vivo might underlie slowing of conduction and axon damage are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.