ArticleGenome biology2008
Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.Molecular systems biology · 2016Article
- Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.BMC medical genomics · 2015Article
- SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.PloS one · 2013Article
- Cross-platform prediction of gene expression signatures.PloS one · 2013Article
- Deriving transcriptional programs and functional processes from gene expression databases.Bioinformatics (Oxford, England) · 2012Article
- SIGNATURE: a workbench for gene expression signature analysis.BMC bioinformatics · 2011Article
- Gene set enrichment; a problem of pathways.Briefings in functional genomics · 2010Article
- A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors.BMC medical genomics · 2010Article
- Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems.BMC systems biology · 2010Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The ability to detect activation of signaling pathways based solely on gene expression data represents an important goal in biological research. We tested the sensitivity of singular value decomposition-based regression by focusing on functional interactions between the Ras and transforming growth factor beta signaling pathways. Our findings demonstrate that this approach is sufficiently sensitive to detect the secondary activation of endogenous signaling pathways as it occurs through crosstalk following ectopic activation of a primary pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.