ArticleBMC evolutionary biology2008
Complex fate of paralogs.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Distinct Evolutionary Trajectories of Major Intracellular Proteolytic Systems in Gilthead Seabream and European Seabass.Biology · 2026Article
- Evolutionary Dynamics of Matrix Metalloproteases with Collagenolytic Activity in Teleosts.Animals : an open access journal from MDPI · 2025Article
- Altered assembly paths mitigate interference among paralogous complexes.Nature communications · 2024Article
- Uncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1.Communications biology · 2023Article
- Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III ineLife · 2022Article
- A Simple Evolutionary Model of Genetic Robustness After Gene Duplication.Journal of molecular evolution · 2022Article
- Yeast Protein Kinase A Isoforms: A Means of Encoding Specificity in the Response to Diverse Stress Conditions?Biomolecules · 2022Review
- Size distribution of function-based human gene sets and the split-merge model.Royal Society open science · 2016Article
- Spatiotemporal variation of mammalian protein complex stoichiometries.Genome biology · 2016Article
- Identical substitutions in magnesium chelatase paralogs result in chlorophyll-deficient soybean mutants.G3 (Bethesda, Md.) · 2014Article
- Evolution of modular intraflagellar transport from a coatomer-like progenitor.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- All or nothing: protein complexes flip essentiality between distantly related eukaryotes.Genome biology and evolution · 2013Article
- Article
- Preferential duplication of intermodular hub genes: an evolutionary signature in eukaryotes genome networks.PloS one · 2013Article
- A three-dimensional topology of complex I inferred from evolutionary correlations.BMC structural biology · 2012Article
- Gene duplications contribute to the overrepresentation of interactions between proteins of a similar age.BMC evolutionary biology · 2012Article
- Enrichment of homologs in insignificant BLAST hits by co-complex network alignment.BMC bioinformatics · 2010Article
- Comparative evolutionary analysis of protein complexes in E. coli and yeast.BMC genomics · 2010Article
- Evolutionary flexibility of protein complexes.BMC evolutionary biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThanks to recent high coverage mass-spectrometry studies and reconstructed protein complexes, we are now in an unprecedented position to study the evolution of biological systems. Gene duplications, known to be a major source of innovation in evolution, can now be readily examined in the context of protein complexes.
resultsWe observe that paralogs operating in the same complex fulfill different roles: mRNA dosage increase for more than a hundred cytosolic ribosomal proteins, mutually exclusive participation of at least 54 paralogs resulting in alternative forms of complexes, and 24 proteins contributing to bona fide structural growth. Inspection of paralogous proteins participating in two independent complexes shows that an ancient, pre-duplication protein functioned in both multi-protein assemblies and a gene duplication event allowed the respective copies to specialize and split their roles.
conclusionVariants with conditionally assembled, paralogous subunits likely have played a role in yeast's adaptation to anaerobic conditions. In a number of cases the gene duplication has given rise to one duplicate that is no longer part of a protein complex and shows an accelerated rate of evolution. Such genes could provide the raw material for the evolution of new functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.