ArticleJournal of neurochemistry2009
Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Microtubule stiffening by the doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in Caenorhabditis elegans.PLoS genetics · 2026Article
- Multiple Regulatory Mechanisms of Post-Translational Modifications and Therapeutic Potential of Mitotic Catastrophe.International journal of molecular sciences · 2026Review
- SPINOPHILIN: A multiplayer tumor suppressor.Genes & diseases · 2023Review
- Profiling Glioblastoma Cases with an Expression of DCX, OLIG2 and NES.International journal of molecular sciences · 2021Article
- Thiolated-Polymer-Based Nanoparticles as an Avant-Garde Approach for Anticancer Therapies-Reviewing Thiomers from Chitosan and Hyaluronic Acid.Pharmaceutics · 2021Review
- Extracellular and Intracellular Factors in Brain Cancer.Frontiers in cell and developmental biology · 2021Review
- Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.Cell communication and signaling : CCS · 2020Article
- The Cytoskeleton-A Complex Interacting Meshwork.Cells · 2019Review
- A single factor induces neuronal differentiation to suppress glioma cell growth.CNS neuroscience & therapeutics · 2019Article
- SOX11: friend or foe in tumor prevention and carcinogenesis?Therapeutic advances in medical oncology · 2019Review
- Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas.BMC cancer · 2018Article
- Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.Neuron · 2015Article
- Deregulated proliferation and differentiation in brain tumors.Cell and tissue research · 2015Review
- Reprogramming the fate of human glioma cells to impede brain tumor development.Cell death & disease · 2014Article
- Adenovirus-mediated coexpression of DCX and SPARC radiosensitizes human malignant glioma cells.Cellular and molecular neurobiology · 2013Article
- Protein phosphatase 1γ isoforms linked interactions in the brain.Journal of molecular neuroscience : MN · 2013Article
- Doublecortin (Dcx) family proteins regulate filamentous actin structure in developing neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Increasing doublecortin expression promotes migration of human embryonic stem cell-derived neurons.Stem cells (Dayton, Ohio) · 2012Article
- Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells.Cancer science · 2011Article
- Single doublecortin gene therapy significantly reduces glioma tumor volume.Journal of neuroscience research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Doublecortin (DCX) is a microtubule (MT) binding protein that induces growth arrest at the G2-M phase of cell cycle in glioma and suppresses tumor xenograft in immunocompromised hosts. DCX expression was found in neuronal cells, but lacking in glioma cells. We tested the hypothesis that DCX inhibits glioma U87 cell mitosis and invasion. Our data showed that DCX synthesizing U87 cells underwent mitotic MT spindle catastrophe in a neurabin II dependent pathway. Synthesis of both DCX and neurabin II were required to induce apoptosis in U87 and human embryonic kidney 293T cells. In DCX expressing U87 cells, association of phosphorylated DCX with protein phosphatase-1 (PP1) in the cytosol disrupted the interaction between kinesin-13 and PP1 in the nucleus and yielded spontaneously active kinesin-13. The activated kinesin-13 caused mitotic MT catastrophe in spindle checkpoint. Phosphorylated-DCX induced depolymerization of actin filaments in U87 cells, down-regulated matrix metalloproteinases-2 and -9, and inhibited glioma U87 cell invasion in a neurabin II dependent pathway. Thus, localization of the DCX-neurabin II-PP1 complex in the cytosol of U87 tumor cells inhibited PP1 phosphatase activities leading to anti-glioma effects via (1) mitotic MT spindle catastrophe that blocks mitosis and (2) depolymerization of actin that inhibits glioma cell invasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.