ArticleJournal of neurochemistry2009
Bi-directional modulation of fast inhibitory synaptic transmission by leptin.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAFrontiers in cellular neuroscience · 2025Article
- Food for Thought: Leptin and Hippocampal Synaptic Function.Frontiers in pharmacology · 2022Review
- Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons.Science signaling · 2021Article
- Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus.Molecular brain · 2020Article
- IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala.Brain, behavior, and immunity · 2019Article
- Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus.Frontiers in cellular neuroscience · 2019Article
- Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons.Brain structure & function · 2018Article
- Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus-Ventral Tegmental Area Neurocircuitry Depends on Energy State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neurosteroids are reduced in diabetic neuropathy and may be associated with the development of neuropathic pain.F1000Research · 2016Article
- Effect of forced exercise and exercise withdrawal on memory, serum and hippocampal corticosterone levels in rats.Experimental brain research · 2015Article
- Leptin induces hippocampal synaptogenesis via CREB-regulated microRNA-132 suppression of p250GAP.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus.Frontiers in cellular neuroscience · 2014Article
- Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.Neuroscience · 2012Article
- NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity.NeuropharmacologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The hormone leptin has widespread actions in the CNS. Indeed, leptin markedly influences hippocampal excitatory synaptic transmission and synaptic plasticity. However, the effects of leptin on fast inhibitory synaptic transmission in the hippocampus have not been evaluated. Here, we show that leptin modulates GABA(A) receptor-mediated synaptic transmission onto hippocampal CA1 pyramidal cells. Leptin promotes a rapid and reversible increase in the amplitude of evoked GABA(A) receptor-mediated inhibitory synaptic currents (IPSCs); an effect that was paralleled by increases in the frequency and amplitude of miniature IPSCs, but with no change in paired pulse ratio or coefficient of variation, suggesting a post-synaptic expression mechanism. Following washout of leptin, a persistent depression (inhibitory long-lasting depression) of evoked IPSCs was observed. Whole-cell dialysis or bath application of inhibitors of phosphoinositide 3 (PI 3)-kinase or Akt prevented leptin-induced enhancement of IPSCs indicating involvement of a post-synaptic PI 3-kinase/Akt-dependent pathway. In contrast, blockade of PI 3-kinase or Akt activity failed to alter the ability of leptin to induce inhibitory long-lasting depression, suggesting that this process is independent of PI 3-kinase/Akt. In conclusion these data indicate that the hormone leptin bi-directionally modulates GABA(A) receptor-mediated synaptic transmission in the hippocampus. These findings have important implications for the role of this hormone in regulating hippocampal pyramidal neuron excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.