ArticleJournal of neurochemistry2008
Amperometric measurements of catecholamine release from single vesicles in MN9D cells.
Article in Journal of neurochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Apoptosis signal-regulating kinase 1 (Frontiers in cellular neuroscience · 2024Article
- Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal-oxide-semiconductor electrode array.Nature communications · 2021Article
- TGF-β Signaling Regulates SLC8A3 Expression and Prevents Oxidative Stress in Developing Midbrain Dopaminergic and Dorsal Raphe Serotonergic Neurons.International journal of molecular sciences · 2020Article
- Fundamentals of fast-scan cyclic voltammetry for dopamine detection.The Analyst · 2020Review
- Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.Oxidative medicine and cellular longevity · 2020Article
- Single-Cell Recording of Vesicle Release From Human Neuroblastoma Cells Using 1024-ch Monolithic CMOS Bioelectronics.IEEE transactions on biomedical circuits and systems · 2018Article
- Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Article
- Surface-modified CMOS IC electrochemical sensor array targeting single chromaffin cells for highly parallel amperometry measurements.Pflugers Archiv : European journal of physiology · 2018Review
- Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line.Cell and tissue research · 2017Article
- New trends in the electrochemical sensing of dopamine.Analytical and bioanalytical chemistry · 2013Review
- Carbon-ring microelectrode arrays for electrochemical imaging of single cell exocytosis: fabrication and characterization.Analytical chemistry · 2012Article
- Dopamine and paraquat enhance α-synuclein-induced alterations in membrane conductance.Neurotoxicity research · 2011Article
- Electroanalytical eavesdropping on single cell communication.Analytical chemistry · 2011Review
- Chemical analysis of single cells.Analytical chemistry · 2011Review
- 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
MN9D cells have been used as a successful model to investigate dopamine pharmacology and to test the specific effects of drugs for the treatment of Parkinson's disease. However, quantitative measurements of quantal release from these cells have not been carried out. In this work, we used amperometry to investigate catecholamine release from MN9D cells. Amperometric events were observed in both undifferentiated and differentiated (butyric acid-treated) cells. An increase in quantal size and half-width was observed for differentiated cells versus undifferentiated cells; however, the number of events per cell and the amplitude remained constant. In transmission electron microscopy images, no obvious cluster of small synaptic vesicles was observed, and large dense-core vesicles were present in the cell body of undifferentiated cells; however, after differentiation, vesicles were concentrated in the cell processes. In differentiated cells, l-DOPA caused an increase in quantal size and half-width, which could be blocked by the vesicular monoamine transporter inhibitor, reserpine.
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Registered trials
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