ReviewDrugs2008
Treatment of nausea and vomiting in terminally ill cancer patients.
Review in Drugs, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- [Pharmacological treatment of malignant bowel obstruction in severely ill and dying patients : a systematic literature review].Schmerz (Berlin, Germany) · 2012Pooled it
- Case Series of Akathisia in Palliative Medicine: Patient Perspective and Efficacy of Procyclidine in Diagnosis and Management.The American journal of hospice & palliative care · 2025Article
- A Comprehensive Analysis of the Association Between the EORTC QLQ-C30 Questionnaire and Cachexia in Patients With Gastric Cancer.Journal of cachexia, sarcopenia and muscle · 2025Article
- Peritoneal carcinomatosis, unilateral malignant pleural effusion with bilateral hydronephrosis post-radical gastrectomy in a signet-ring gastric cancer patient: a case report.Journal of community hospital internal medicine perspectives · 2020Article
- Pancreatic cancer-improved care achievable.World journal of gastroenterology · 2014Review
- Predictors of response to palliative care intervention for chronic nausea in advanced cancer outpatients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Evidence for the use of Levomepromazine for symptom control in the palliative care setting: a systematic review.BMC palliative care · 2013Article
- Treatment of chemotherapy-induced nausea and vomiting.Journal of gastrointestinal cancer · 2012Review
- Drug interactions in dying patients: a retrospective analysis of hospice inpatients in Germany.Drug safety · 2012Article
- [Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients : a review].Schmerz (Berlin, Germany) · 2012Review
- Palliation of gastrointestinal obstruction.Canadian family physician Medecin de famille canadien · 2012Article
- 84-year-old man with respiratory distress and abdominal distention.Mayo Clinic proceedings · 2011Article
- Treating nausea and vomiting in palliative care: a review.Clinical interventions in aging · 2011Review
- Medication Repurposing in Pediatric Patients: Teaching Old Drugs New Tricks.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nausea and vomiting is a common and distressing symptom complex in patients with far-advanced cancer, affecting up to 60% of individuals at some stage of their illness. The current approach to the palliative care of patients with nausea and vomiting is based on identifying the cause, understanding its pathophysiology and knowing the pharmacology of the drugs available for its amelioration. The following six main syndromes are identified: gastric stasis, biochemical, raised intracranial pressure, vestibular, mechanical bowel obstruction and ileus. A careful history, focused physical examination and appropriate investigations are needed to elucidate the syndrome and its cause, so that therapy is rational. Drugs are the mainstay of treatment in terminal cancer, and the main classes of antiemetic agents are prokinetics, dopamine antagonists, antihistamines, anticholinergics and serotonin antagonists. Dexamethasone and octreotide are also used, especially in bowel obstruction. Non-drug measures are important in relieving the associated distress. Patients should be able to die comfortably, without tubes. Despite decades of practice affirming this approach, the evidence base is weak and well designed studies are urgently needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.