ArticleClinical reviews in allergy & immunology2009
Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis: risk factors for accelerated macrovascular damage?
Article in Clinical reviews in allergy & immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Gut microbiome and metabolomics in systemic sclerosis: feature, link and mechanisms.Frontiers in immunology · 2024Review
- Metabolic fingerprinting of systemic sclerosis: a systematic review.Frontiers in molecular biosciences · 2023Review
- Micronutrient Deficiencies in Systemic Sclerosis: A Scoping Review.Open access rheumatology : research and reviews · 2022Article
- Hydrogen Sulfide: A Therapeutic Option in Systemic Sclerosis.International journal of molecular sciences · 2018Review
- Prevalence of variants in methylenetetrahydrofolate reductase and the severity of pulmonary vascular disease.Pediatric cardiology · 2015Article
- Serum homocystein level in patients with scleroderma.Iranian Red Crescent medical journal · 2013Article
- Multiparametric assessment of vascular function and atherosclerosis in patients with autoimmune gastritis: a comparative study.Digestive diseases and sciences · 2011Article
- Lower extremity ulcers in systemic sclerosis: features and response to therapy.International journal of rheumatology · 2010Article
- Vascular involvement in rheumatic diseases: 'vascular rheumatology'.Arthritis research & therapy · 2008Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate plasma homocysteine (Hcy) levels in patients with systemic sclerosis (SSc) and to study the association between plasma Hcy, C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR), and the clinical manifestations in SSc. Associations of Hcy level, C677T MTHFR polymorphism, and macrovascular diseases were investigated in 152 patients with SSc and 58 controls. No significant differences in Hcy levels and MTHFR genotypes were found in SSc patients compared to controls or in SSc patients with limited cutaneous compared to diffuse disease. Significantly higher Hcy concentration was observed in patients with macroangiopathy/thromboembolic events compared to patients without such clinical manifestations (p < 0.05). There was significant correlation between age and macrovascular disorders, between Hcy level and the disease duration (r = 0.164; p < 0.05). Seventy-one percent of patients with macrovascular disorders had MTHFR polymorphism. In addition, 45% of patients with hyperhomocysteinemia had pulmonary hypertension. The presence of MTHFR C677T mutation influences the incidence of macrovascular abnormalities in SSc patients. Elevated Hcy levels may be associated with disease duration and the evolution of macrovascular disorders and pulmonary hypertension in SSc.
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