ArticleDisease models & mechanisms
Zebrafish myelination: a transparent model for remyelination?
Article in Disease models & mechanisms. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 69 citations in OpenAlex.
- Complex Sound Discrimination in Zebrafish: Auditory Learning Within a Novel "Go/Go" Decision-Making Paradigm.Animals : an open access journal from MDPI · 2025Article
- From Molecules to Models: miRNAs and Advanced Human Platforms of Neurodegeneration and Repair in Multiple Sclerosis.International journal of molecular sciences · 2025Review
- Assessment of Replicability and Efforts to Refine an Operant Conditioning Procedure for Larval Zebrafish.Animals : an open access journal from MDPI · 2024Article
- Zebrafish as a Model for Multiple Sclerosis.Biomedicines · 2024Review
- Deletion of theInternational journal of molecular sciences · 2023Article
- Oligodendrocyte origin and development in the zebrafish visual system.The Journal of comparative neurology · 2023Article
- Lysophosphatidic acid signaling via LPAJournal of neurochemistry · 2022Article
- Article
- The Current Challenges for Drug Discovery in CNS Remyelination.International journal of molecular sciences · 2021Review
- Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.Theranostics · 2021Article
- Article
- In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development.Annals of the New York Academy of Sciences · 2019Article
- An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination.eLife · 2018Article
- Hypoxia Delays Oligodendrocyte Progenitor Cell Migration and Myelin Formation by Suppressing Bmp2b Signaling in Larval Zebrafish.Frontiers in cellular neuroscience · 2018Article
- Models for Studying Myelination, Demyelination and Remyelination.Neuromolecular medicine · 2017Review
- Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish.Disease models & mechanisms · 2016Article
- The scales and tales of myelination: using zebrafish and mouse to study myelinating glia.Brain research · 2016Review
- Review
- Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.Nature medicine · 2014Article
- EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.Nature communications · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is currently an unmet need for a therapy that promotes the regenerative process of remyelination in central nervous system diseases, notably multiple sclerosis (MS). A high-throughput model is, therefore, required to screen potential therapeutic drugs and to refine genomic and proteomic data from MS lesions. Here, we review the value of the zebrafish (Danio rerio) larva as a model of the developmental process of myelination, describing the powerful applications of zebrafish for genetic manipulation and genetic screens, as well as some of the exciting imaging capabilities of this model. Finally, we discuss how a model of zebrafish myelination can be used as a high-throughput screening model to predict the effect of compounds on remyelination. We conclude that zebrafish provide a highly versatile myelination model. As more complex transgenic zebrafish lines are developed, it might soon be possible to visualise myelination, or even remyelination, in real time. However, experimental outputs must be designed carefully for such visual and temporal techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.