ArticleEuropean journal of human genetics : EJHG2009
Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource.
Article in European journal of human genetics : EJHG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.European journal of human genetics : EJHG · 2010Pooled it
- Association betweenDiagnostics (Basel, Switzerland) · 2023Article
- Familial clustering of ALS in a population-based resource.Neurology · 2014Article
- An understanding of the genetic basis of asthma.The Indian journal of medical research · 2011Review
- Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees.Molecular autism · 2010Article
- An application of the latent p value method to assess linkage in asthma pedigrees.Human heredity · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Asthma is a multifactorial disease with undetermined genetic factors. We performed a genome-wide scan to identify predisposition loci for asthma. The asthma phenotype consisted of physician-confirmed presence or absence of asthma symptoms. We analyzed 81 extended Utah pedigrees ranging from three to six generations, including 742 affected individuals, ranging from 2 to 40 per pedigree. We performed parametric multipoint linkage analyses with dominant and recessive models. Our analysis revealed genome-wide significant evidence of linkage to region 5q13 (log of the odds ratio (LOD)=3.8, recessive model), and suggestive evidence for linkage to region 6p21 (LOD=2.1, dominant model). Both the 5q13 and 6p21 regions indicated in these analyses have been previously identified as regions of interest in other genome-wide scans for asthma-related phenotypes. The evidence of linkage at the 5q13 region represents the first significant evidence for linkage on a genome-wide basis for this locus. Linked pedigrees localize the region to approximately between 92.3-105.5 Mb.
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Registered trials
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