ReviewJournal of endocrinological investigation2008
Effects of endurance exercise on the reproductive system of men: the "exercise-hypogonadal male condition".
Review in Journal of endocrinological investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Endogenous transient doping: physical exercise acutely increases testosterone levels-results from a meta-analysis.Journal of endocrinological investigation · 2020Pooled it
- Effects of continuous isomaltulose-containing gummy intake on interstitial glucose and salivary hormones during an 18-hole golf round: a randomized, double-blind controlled pilot study.Journal of the International Society of Sports Nutrition · 2026Trial
- Muscle and intestinal damage in triathletes.PloS one · 2019Trial
- Trial
- Endocrine and neuromodulatory regulation during prolonged maximal 6000-m rowing in male athletes.European journal of applied physiology · 2026Article
- Long-term endurance running training and testosterone daily variation in ageing men; a comparative cross-sectional study.Experimental physiology · 2026Article
- Stress-associated testosterone suppression: central adaptation or hypogonadism?The Journal of clinical endocrinology and metabolism · 2026Review
- Review
- Sexual Function and Libido Loss in Female Climbers-A Cross-Sectional Study.Sports (Basel, Switzerland) · 2026Article
- Stages and Characteristics of Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Ligandrol lowers endurance and negatively affects lipid and hormonal profile of male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- A prospective study of male physical activity and fecundability.Human reproduction (Oxford, England) · 2025Article
- The Influence of an Intense Training Regime in Professional and Non-Professional Athletes on Semen Parameters: A Systematic Review.Journal of clinical medicine · 2025Review
- Does Relative Energy Deficiency in Sport (REDs) Syndrome Exist?Sports medicine (Auckland, N.Z.) · 2024Review
- Unraveling the complexity of the impact of physical exercise on male reproductive functions: a review of both sides of a coin.Frontiers in physiology · 2024Review
- Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms.Cancers · 2023Review
- Exercise-related changes in the anabolic index (testosterone to cortisol ratio) and serum amyloid A concentration in endurance and racehorses at different fitness levels.Frontiers in veterinary science · 2023Article
- Prevalence of Triad-RED-S symptoms in high-level Kenyan male and female distance runners and corresponding control groups.European journal of applied physiology · 2022Observational
- Correlations between Basal Trace Minerals and Hormones in Middle and Long-Distance High-Level Male Runners.International journal of environmental research and public health · 2020Article
- Vitamin D, sport and health: a still unresolved clinical issue.Journal of endocrinological investigation · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increasing number of investigative research studies point to participation in endurance exercise training as having significant detrimental effects upon reproductive hormonal profiles in men. Specifically, men chronically exposed to this type of exercise training exhibit persistently reduced basal (resting-state) free and total testosterone concentrations without concurrent LH elevations. Men displaying these symptoms have been deemed to exhibit the "exercise-hypogonadal male condition". The exact physiological mechanism inducing the reduction of testosterone in these men is currently unclear, but is postulated to be a dysfunction (or perhaps a readjustment) within the hypothalamic-pituitary-testicular regulatory axis. The potential exists for the reduced testosterone concentrations within exercise-hypogonadal men to be disruptive and detrimental to some anabolic-androgenic testosterone- dependent physiological processes. Findings on this point are limited, but do suggest spermatogenesis problems may exist in some cases. Alternatively, reductions in circulating testosterone concentrations could have cardiovascular protective effects and thus be beneficial to the health of these men. Present evidence suggests the exercise-hypogonadal condition is limited to men who have been persistently involved in chronic endurance exercise training for an extended period time (i.e., years), and it is not a highly prevalent occurrence (although, a thorough epidemiological investigation on the topic is lacking in the literature). Many questions regarding the male reproductive endocrine adaptive process to exercise training still remain unanswered, necessitating the need for much further investigation on the topic, especially with respect to the exercise-hypogonadal condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.