ArticleNeurology2009
Yield of combined perfusion and diffusion MR imaging in hemispheric TIA.
Article in Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 122 citations in OpenAlex.
- Significance of arterial spin labeling perfusion and susceptibility weighted imaging changes in patients with transient ischemic attack: a prospective cohort study.BMC medical imaging · 2018Trial
- Trial
- Focal Hypoperfusion on Baseline Perfusion-Weighted MRI and the Risk of Subsequent Cerebrovascular Events in Patients With TIA.Neurology · 2025Article
- Not So Transient?: A Narrative Review on Cognitive Impairment After Transient Ischemic Attack.Stroke · 2024Review
- Transient Ischemic Attack Outpatient Clinic: Past Journey and Future Adventure.Journal of clinical medicine · 2023Review
- High-resolution dynamic susceptibility contrast perfusion imaging using higher-order temporal smoothness regularization.Magnetic resonance in medicine · 2023Article
- European Stroke Organisation (ESO) guidelines on management of transient ischaemic attack.European stroke journal · 2021Article
- Systematic Review and Meta-Analysis of Diagnostic Agreement in Suspected TIA.Neurology. Clinical practice · 2021Review
- Power of Hypoperfusion in Predicting Recurrent Transient Ischemic Attacks: Protocol of a Prospective Cohort Study.Frontiers in human neuroscience · 2021Article
- Addition of arterial spin-labelled MR perfusion to conventional brain MRI: clinical experience in a retrospective cohort study.BMJ open · 2020Article
- Fluid-Attenuated Inversion Recovery Vascular Hyperintensities in Transient Ischemic Attack within the Anterior Circulation.BioMed research international · 2020Article
- Risk factors of perfusion and diffusion abnormalities on MRI in hemispheric TIA: a case-control study.Annals of translational medicine · 2019Article
- Neural Network-derived Perfusion Maps for the Assessment of Lesions in Patients with Acute Ischemic Stroke.Radiology. Artificial intelligence · 2019Article
- Non-invasive evaluation of cerebral perfusion in patients with transient ischemic attack: an fMRI study.Journal of neurology · 2019Article
- History of Hypertension Is Associated With MR Hypoperfusion in Chinese Inpatients With DWI-Negative TIA.Frontiers in neurology · 2019Article
- Early MRI-negative posterior circulation stroke presenting as acute dizziness.Journal of neurology · 2018Article
- Emergency Department (ED) Triage for Transient Ischemic Attack (TIA).Current atherosclerosis reports · 2018Review
- Small cortical grey matter lesions show no persistent infarction in transient ischaemic attack? A prospective cohort study.BMJ open · 2018Observational
- Changes to white matter microstructure in transient ischemic attack: A longitudinal diffusion tensor imaging study.Human brain mapping · 2017Article
- Comparison of 3- and 20-Gradient Direction Diffusion-Weighted Imaging in a Clinical Subacute Cohort of Patients with Transient Ischemic Attack: Application of Standard Vendor Protocols for Lesion Detection and Final Infarct Size Projection.Frontiers in neurology · 2017Article
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTransient ischemic attacks (TIA) predict future stroke. However, there are no sensitive and specific diagnostic criteria for TIA and interobserver agreement regarding the diagnosis is poor. Diffusion-weighted MRI (DWI) demonstrates acute ischemic lesions in approximately 30% of TIA patients; the yield of perfusion-weighted MRI (PWI) is unclear.
methodsWe prospectively performed both DWI and PWI within 48 hours of symptom onset in consecutive patients admitted with suspected hemispheric TIAs of <24 hours symptom duration. Two independent raters, blinded to clinical features, assessed the presence and location of acute DWI and PWI lesions. Lesions were correlated with suspected clinical localization and baseline characteristics. Clinical features predictive of a PWI lesion were assessed.
resultsForty-three patients met the inclusion criteria. Thirty-three percent had a PWI lesion and 35% had a DWI lesion. Seven patients (16%) had both PWI and DWI lesions and 7 (16%) had only PWI lesions. The combined yield for identification of either a PWI or a DWI was 51%. DWI lesions occurred in the clinically suspected hemisphere in 93% of patients; PWI lesions in 86%. PWI lesions occurred more frequently when the MRI was performed within 12 hours of symptom resolution, in patients with symptoms of speech impairment, and among individuals younger than 60 years.
conclusionsThe combination of early diffusion-weighted MRI and perfusion-weighted MRI can document the presence of a cerebral ischemic lesion in approximately half of all patients who present with a suspected hemispheric transient ischemic attack (TIA). MRI has the potential to improve the accuracy of TIA diagnosis. ACA = anterior cerebral artery; CI = confidence interval; DWI = diffusion-weighted MRI; ICA = internal carotid artery; MCA = middle cerebral artery; MRA = magnetic resonance angiography; MTT = mean transit time; OR = odds ratios; PCA = posterior cerebral artery; PWI = perfusion-weighted MRI; RR = risk ratios; TIA = transient ischemic attacks; TOAST = Trial of Org 10172 in Acute Stroke Treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.