Evidence map›Paper›PMID 19091994›Full record

ArticleClinical and vaccine immunology : CVI2009

Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques.

Michael D George, David Verhoeven, Sumathi Sankaran, Tiffany Glavan, Elizabeth Reay, Satya Dandekar

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Microbiome in human immunodeficiency virus infection.Clinics in laboratory medicine · 2014
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael D GeorgeDepartment of Medical Microbiology, School of Medicine, University of California, Davis, California 95616, USA. mdgeorge@ucdavis.edu
David Verhoeven
Sumathi Sankaran
Tiffany Glavan
Elizabeth Reay
Satya Dandekar
University of California Davis Medical Center · US

Funding

PATHOGENESIS OF INTESTINAL DYSFUNCTION IN SIMIAN AIDSR01DK043183 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI DANDEKAR, SATYA · 1992 to 2010
$2.9M
Host Response and Pathogenesis in the Oral Cavity during SIV InfectionR21DE018097 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GEORGE, MICHAEL D. · 2007 to 2008
$416k
NIDCR NIH HHS 1R21DE018097NIDCR NIH HHS R21 DE018097NIDDK NIH HHS R01 DK043183NIDDK NIH HHS R01DK43183
6 · The paper itself

Abstract

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

Indexed as

Cytotoxicity, ImmunologicAnimalsCD4-Positive T-LymphocytesCytokinesGene Expression ProfilingHumansKiller Cells, NaturalMacaca mulattaMouth MucosaSimian Immunodeficiency VirusCytokines

Identifiers

PMID19091994
PMCPMC2643550
OpenAlexW2141918796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.