ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
T1R3 taste receptor is critical for sucrose but not Polycose taste.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 141 citations in OpenAlex.
- Trial
- Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.The Journal of biological chemistry · 2013Trial
- Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice.Nature communications · 2026Article
- Noncanonical Taste Transduction of Sugars Elicits Responses in a Dedicated Subset of Gustatory Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Gustatory and olfactory-guided responsiveness to maltodextrin solutions in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- BuZhong YiQi Formula Alleviates Taste Disorders in Rats with Type 2 Diabetes Mellitus by Increasing the Number of Taste Buds and the Expression of Signaling Molecules in Taste Transduction Pathways.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- TRPM4 and PLCβ3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCβ3 is not needed for taste-driven licking for glucose.Chemical senses · 2024Article
- Altered peripheral taste function in a mouse model of inflammatory bowel disease.Scientific reports · 2023Article
- Taste Detection of Maltooligosaccharides with Varying Degrees of Polymerization.Journal of agricultural and food chemistry · 2023Article
- Article
- Dietary experience with glucose and fructose fosters heightened avidity for glucose-containing sugars independent of TRPM5 taste transduction in mice.Nutritional neuroscience · 2023Article
- A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.Physiology & behavior · 2022Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- Recovery of sweet taste preference in adult rats following bilateral chorda tympani nerve transection.PeerJ · 2022Article
- Taste perception of cyclic oligosaccharides: α, β, and γ cyclodextrins.Chemical senses · 2022Article
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- Nutrient-conditioned intake stimulation does not require a distinctive flavor cue in rats.Appetite · 2020Article
- Residual Glucose Taste in T1R3 Knockout but not TRPM5 Knockout Mice.Physiology & behavior · 2020Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In addition to their well-known preference for sugars, mice and rats avidly consume starch-derived glucose polymers (e.g., Polycose). T1R3 is a component of the mammalian sweet taste receptor that mediates the preference for sugars and artificial sweeteners in mammals. We examined the role of the T1R3 receptor in the ingestive response of mice to Polycose and sucrose. In 60-s two-bottle tests, knockout (KO) mice preferred Polycose solutions (4-32%) to water, although their overall preference was lower than WT mice (82% vs. 94%). KO mice also preferred Polycose (0.5-32%) in 24-h two-bottle tests, although less so than WT mice at dilute concentrations (0.5-4%). In contrast, KO mice failed to prefer sucrose to water in 60-s tests. In 24-h tests, KO mice were indifferent to 0.5-8% sucrose, but preferred 16-32% sucrose; this latter result may reflect the post-oral effects of sucrose. Overall sucrose preference and intake were substantially less in KO mice than WT mice. However, when retested with 0.5-32% sucrose solutions, the KO mice preferred all sucrose concentrations, although they drank less sugar than WT mice. The experience-induced sucrose preference is attributed to a post-oral conditioned preference for the T1R3-independent orosensory features of the sugar solutions (odor, texture, T1R2-mediated taste). Chorda tympani nerve recordings revealed virtually no response to sucrose in KO mice, but a near-normal response to Polycose. These results indicate that the T1R3 receptor plays a critical role in the taste-mediated response to sucrose but not Polycose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.