ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function.World journal of gastroenterology · 2026Article
- Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure.Nature reviews. Cardiology · 2025Article
- Effects of bile duct ligation on the inhibitory control of supraoptic vasopressin neurons.Journal of neuroendocrinology · 2023Article
- Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels.Frontiers in pharmacology · 2023Article
- Regulation of ThermoTRP Channels by PIP2 and Cholesterol.Advances in experimental medicine and biology · 2023Article
- Norepinephrine innervation of the supraoptic nucleus contributes to increased copeptin and dilutional hyponatremia in male rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology.Endocrinology · 2021Review
- Sex Differences in the Regulation of Vasopressin and Oxytocin Secretion in Bile Duct-Ligated Rats.Neuroendocrinology · 2021Article
- Role of Transient Receptor Potential Vanilloid 4 in Vascular Function.Frontiers in molecular biosciences · 2021Review
- Brain-Derived Neurotrophic Factor and Supraoptic Vasopressin Neurons in Hyponatremia.Neuroendocrinology · 2020Article
- Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging.Journal of neuroendocrinology · 2019Article
- Transient receptor potential vanilloid type 4 is expressed in vasopressinergic neurons within the magnocellular subdivision of the rat paraventricular nucleus of the hypothalamus.The Journal of comparative neurology · 2018Article
- High salt loading increases brain derived neurotrophic factor in supraoptic vasopressin neurones.Journal of neuroendocrinology · 2018Article
- Dysregulation of the Renin-Angiotensin System and the Vasopressinergic System Interactions in Cardiovascular Disorders.Current hypertension reports · 2018Review
- Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles.Frontiers in physiology · 2018Review
- Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.Free radical biology & medicine · 2017Article
- TRPV4 is associated with central rather than nephrogenic osmoregulation.Pflugers Archiv : European journal of physiology · 2016Article
- TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus.British journal of pharmacology · 2015Article
- The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734.Frontiers in pharmacology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Inappropriate vasopressin (AVP) release causes dilutional hyponatremia in many pathophysiological states such as cirrhosis. The central molecular mechanisms that mediate inappropriate AVP release are unknown. We tested the hypothesis that changes in the expression or trafficking of TRPV4 in the central nervous system may contribute to inappropriate AVP release in the bile duct ligation (BDL) model of cirrhosis in the rat. Four weeks after surgery, BDL rats demonstrated significantly increased plasma vasopressin and plasma renin activity (PRA), hypervolemia, and decreased plasma osmolality. These effects were blocked by providing BDL rats with 2% saline to drink for 15 days. TRPV4 protein expression was significantly increased in brain punches from BDL rats containing the supraoptic nucleus (SON) of the hypothalamus (100% +/- 11 to 157% +/- 4.8), and this effect was blocked in BDL rats given saline. Immunohistochemistry demonstrated a significant increase in TRPV4-positive cells and the percentage of AVP neurons that also were TRPV4-positive in the SON of BDL rats. In the hypothalamus of BDL rats, TRPV4 lipid raft association increased compared with sham (from 100% +/- 2.1 to 326.1% +/- 16). This effect was significantly attenuated in BDL rats given 2% saline to drink (174% +/- 11). In the brain stem, TRPV4 lipid raft association was reduced by BDL and inversely related to plasma AVP and PRA. We speculate that changes in TRPV4 expression and compartmentalization within lipid rafts could contribute to a feed-forward mechanism related to AVP release in cirrhosis.
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