ArticleBMC evolutionary biology2008
Similar rates of protein adaptation in Drosophila miranda and D. melanogaster, two species with different current effective population sizes.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Does effective population size affect rates of molecular evolution: Mitochondrial data for host/parasite species pairs in bees suggests not.Ecology and evolution · 2022Article
- Variation of natural selection in the Amoebozoa reveals heterogeneity across the phylogeny and adaptive evolution in diverse lineages.Frontiers in ecology and evolution · 2022Article
- Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster.Molecular biology and evolution · 2019Article
- Determinants of the Efficacy of Natural Selection on Coding and Noncoding Variability in Two Passerine Species.Genome biology and evolution · 2017Article
- Robust forward simulations of recurrent hitchhiking.Genetics · 2014Article
- Article
- Kr/Kc but not dN/dS correlates positively with body mass in birds, raising implications for inferring lineage-specific selection.Genome biology · 2014Article
- ZRT1 Harbors an Excess of Nonsynonymous Polymorphism and Shows Evidence of Balancing Selection in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2013Article
- Drosophila americana as a model species for comparative studies on the molecular basis of phenotypic variation.Genome biology and evolution · 2013Article
- Adaptive evolution and effective population size in wild house mice.Molecular biology and evolution · 2012Article
- Weak selection and protein evolution.Genetics · 2012Review
- Evidence for widespread positive and purifying selection across the European rabbit (Oryctolagus cuniculus) genome.Molecular biology and evolution · 2012Article
- Article
- Estimating the rate of adaptive molecular evolution when the evolutionary divergence between species is small.Journal of molecular evolution · 2012Article
- Methods to detect selection on noncoding DNA.Methods in molecular biology (Clifton, N.J.) · 2012Review
- A method for inferring the rate of occurrence and fitness effects of advantageous mutations.Genetics · 2011Article
- Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.PLoS genetics · 2011Article
- Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race.BMC evolutionary biology · 2011Article
- Weighing the evidence for adaptation at the molecular level.Trends in genetics : TIG · 2011Article
- Effective population size is positively correlated with levels of adaptive divergence among annual sunflowers.Molecular biology and evolution · 2011Article
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Abstract
backgroundAdaptive protein evolution is common in several Drosophila species investigated. Some studies point to very weak selection operating on amino-acid mutations, with average selection intensities on the order of Nes approximately in D. melanogaster and D. simulans. Species with lower effective population sizes should undergo less adaptation since they generate fewer mutations and selection is ineffective on a greater proportion of beneficial mutations.
resultsHere I study patterns of polymorphism and divergence at 91 X-linked loci in D. miranda, a species with a roughly 5-fold smaller effective population size than D. melanogaster. Surprisingly, I find a similar fraction of amino-acid mutations being driven to fixation by positive selection in D. miranda and D. melanogaster. Genes with higher rates of amino-acid evolution show lower levels of neutral diversity, a pattern predicted by recurrent adaptive protein evolution. I fit a hitchhiking model to patterns of polymorphism in D. miranda and D. melanogaster and estimate an order of magnitude higher selection coefficients for beneficial mutations in D. miranda.
conclusionThis analysis suggests that effective population size may not be a major determinant in rates of protein adaptation. Instead, adaptation may not be mutation-limited, or the distribution of fitness effects for beneficial mutations might differ vastly between different species or populations. Alternative explanation such as biases in estimating the fraction of beneficial mutations or slightly deleterious mutation models are also discussed.
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