ReviewBMC neuroscience2008
Small molecule activators of the Trk receptors for neuroprotection.
Review in BMC neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Neuroprotective Metabolites from Vietnamese Marine Derived Fungi ofMarine drugs · 2020Article
- Donepezil improves the cognitive impairment in a tree shrew model of Alzheimer's disease induced by amyloid-βMetabolic brain disease · 2018Article
- The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.Bosnian journal of basic medical sciences · 2018Article
- Article
- A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model.Scientific reports · 2017Article
- Modulation of neurotrophic signaling pathways by polyphenols.Drug design, development and therapy · 2016Review
- Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders.Neuromolecular medicine · 2015Review
- Gram-scale, chemoselective synthesis ofTetrahedron letters · 2015Article
- Brain-derived neurotrophic factor in the airways.Pharmacology & therapeutics · 2014Review
- Neurotrophic natural products: chemistry and biology.Angewandte Chemie (International ed. in English) · 2014Review
- Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases.BioMed research international · 2014Review
- 5-HT7 receptor activation promotes an increase in TrkB receptor expression and phosphorylation.Frontiers in behavioral neuroscience · 2014Article
- From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF).Pharmaceutics · 2013Article
- CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.PloS one · 2013Article
- A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery.Journal of the Royal Society, Interface · 2012Review
- Effects of lateral ventricular transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene on cognition in a rat model of Alzheimer's disease.Neural regeneration research · 2012Article
- Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus.Neuropharmacology · 2011Article
- Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.The Journal of clinical investigation · 2011Article
- Neurotrophins in lung health and disease.Expert review of respiratory medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The neurotrophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins to prevent this loss is hampered, however, by a number of pharmacological challenges. These include a lack of transport across the blood-brain barrier, rapid degradation in the circulation, and difficulty in production. In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.