ReviewArthritis research & therapy2008
NOD-like receptors and inflammation.
Review in Arthritis research & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Transcriptomic evidence suggesting a Trojan horse-like synergistic effect in exposures to nanoplastics and benzo[a]pyrene on a yellowfin sea bream muscle derived cell line.Journal of fish biology · 2026Article
- Sub-neutralizing levels of antibodies against RSV F protein enhance RSV infection via Fc-FcγR interactions.Frontiers in immunology · 2025Article
- NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells.Odontology · 2024Article
- Recombinant SpTransformer proteins are functionally diverse for binding and phagocytosis by three subtypes of sea urchin phagocytes.Frontiers in immunology · 2024Article
- Hyperoxia Provokes Time- and Dose-Dependent Gut Injury and Endotoxemia and Alters Gut Microbiome and Transcriptome in Mice.Frontiers in medicine · 2021Article
- Nucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection ofLaboratory animal research · 2018Article
- Tissue-specific expression pattern and histological distribution of NLRP3 in Chinese yellow chicken.Veterinary research communications · 2015Article
- Ultrasonographic assessment reveals detailed distribution of synovial inflammation in Blau syndrome.Arthritis research & therapy · 2014Article
- Research progress on the NLRP3 inflammasome and its role in the central nervous system.Neuroscience bulletin · 2013Review
- Pyrin- and CARD-only Proteins as Regulators of NLR Functions.Frontiers in immunology · 2013Review
- Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis.PloS one · 2011Article
- Extracellular matrix from porcine small intestinal submucosa (SIS) as immune adjuvants.PloS one · 2011Article
- Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels.PloS one · 2009Article
- Inflammation: canakinumab for the cryopyrin-associated periodic syndromes.Nature reviews. Rheumatology · 2009Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases, as well as some more common polygenic conditions. Bacterial wall constituents and other cellular stressor molecules are recognized by a range of NLRs, which leads to activation of the innate immune response and upregulation of key proinflammatory pathways, such as IL-1beta production and translocation of nuclear factor-kappaB to the nucleus. These signalling pathways are increasingly being targeted as potential sites for new therapies. This review discusses the role played by NLRs in a variety of inflammatory diseases and describes the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.