Trial reportThe Journal of infectious diseases2009
Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana.
Trial report in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Botswana Diarrheal Diseases Study
Botswana Pediatric Respiratory Disease and Bloodstream Infection
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- HIV-free survival at 12-24 months in breastfed infants of HIV-infected women on antiretroviral treatment.Tropical medicine & international health : TM & IH · 2016Pooled it
- Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.The Cochrane database of systematic reviews · 2011Pooled it
- Infant feeding practices were not associated with breast milk HIV-1 RNA levels in a randomized clinical trial in Botswana.AIDS and behavior · 2012Trial
- Temporal reduction of HIV type 1 viral load in breast milk by single-dose nevirapine during prevention of MTCT.AIDS research and human retroviruses · 2009Trial
- Article
- Does the national program of prevention of mother to child transmission of HIV (PMTCT) reach its target in Ouagadougou, Burkina Faso?African health sciences · 2014Article
- Maternal risk factors for HIV infection in infants in northeastern Brazil.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2013Article
- Dynamics of breast milk HIV-1 RNA with unilateral mastitis or abscess.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Antiretroviral treatment, viral load of mothers & perinatal HIV transmission in Mumbai, India.The Indian journal of medical research · 2013Article
- HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.PloS one · 2012Article
- Withholding breast milk for HIV exposed infants in sub-Saharan Africa: benefit or harm?African health sciences · 2011Article
- Article
- Secondary immunodeficiencies, including HIV infection.The Journal of allergy and clinical immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
Risk factors for mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) via breast-feeding were evaluated in a randomized trial. HIV-infected women and their infants received zidovudine as well as single-dose nevirapine or placebo. Infants were randomized to formula-feed (FF) or breast-feed (BF) in combination with zidovudine prophylaxis. Of 1116 at-risk infants, 6 (1.1%) in the FF group and 7 (1.3%) in the BF group were infected between birth and 1 month (P=.99). Maternal receipt of nevirapine did not predict early MTCT in the BF group (P=.45). Of 547 infants in the BF group at risk for late MTCT, 24 (4.4%) were infected. Maternal HIV-1 RNA levels in plasma (P<.001) and breast milk (P<.001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis. Trial registration. ClinicalTrials.gov identifiers: NCT00197691 and NCT00197652.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.