ArticleProceedings of the National Academy of Sciences of the United States of America1991
Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity.Communications biology · 2025Article
- Article
- Basic research in HIV vaccinology is hampered by reductionist thinking.Frontiers in immunology · 2012Article
- Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens.Biochemical and biophysical research communications · 2009Article
- Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1.Molecular immunology · 2009Article
- Identifying epitopes of HIV-1 that induce protective antibodies.Nature reviews. Immunology · 2004Review
- Molecular determinants of the human antibody response to HIV-1: implications for disease control.Journal of clinical immunology · 2001Article
- Lupus-specific antibodies reveal an altered pattern of somatic mutation.The Journal of clinical investigation · 1997Article
- Identification of an idiotypic peptide recognized by autoantibodies in human immunodeficiency virus-1-infected individuals.The Journal of clinical investigation · 1995Article
- Human autoantibody recognition of DNA.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- HIV-mediated B-lymphocyte activation and lymphomagenesis.Journal of clinical immunology · 1995Review
- The molecular structure of human antibodies specific for the human immunodeficiency virus.Journal of clinical immunology · 1995Review
- Enhanced in vitro human immunodeficiency virus type 1 replication in B cells expressing surface antibody to the TM Env protein.Journal of virology · 1994Article
- VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection.Journal of immunology (Baltimore, Md. : 1950) · 1994Article
- Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase.International immunology · 1993Article
- Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.Journal of immunology (Baltimore, Md. : 1950) · 1993Article
- Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis.The Journal of experimental medicine · 1993Article
- Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.The Journal of clinical investigation · 1992Article
- Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.The Journal of clinical investigation · 1992Article
- B-lymphocytes and autoantibody profiles in HIV disease.Clinical reviews in allergy & immunologyReview
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4 authors.
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Abstract
We report the heavy chain variable region sequences from the cDNAs of five previously described monoclonal cell lines producing human antibodies specific for the human immunodeficiency virus type 1 and detail the molecular characteristics, germ-line origins, and extent of somatic mutation among these antibodies. Three of the five heavy chain variable regions derive from the VHIV gene family, but each has arisen from a different heavy chain variable region (VH) gene segment within the VHIV family. In addition, one is derived from a VHI gene segment, and one is derived from a VHV gene segment. Since four of the five antibodies arise from known germ-line VH elements, a precise determination of the extent of somatic variation is possible. The amount of variation from the closest germ-line sequence ranges from 4.5% to 14.8% among these antibodies, most of which is concentrated in the complementarity-determining regions. In general, the diversity (D) segments are long, characteristic of D-D fusions and/or extensive terminal deoxynucleotidyltransferase activity; however, definitive homologies cannot be found with the known germ-line D segments. Joining (JH) gene segment utilization appears random. The use of five different germ-line VH gene segments and extensive somatic mutation provides evidence that a polyclonal, antigen-driven immune response occurs during the natural infection with human immunodeficiency virus.
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