Evidence map›Paper›PMID 19089684›Full record

ArticleCritical reviews in biochemistry and molecular biology

RNA under attack: cellular handling of RNA damage.

Elisabeth J Wurtmann, Sandra L Wolin

Abstract read
In one paragraph

Article in Critical reviews in biochemistry and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 1 synthesis or guideline pooled it, 266 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Attomolar Detection of HIV-1 With Label-Free RCA-rCRISPR on Smartphone.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Strand Structure Controls Photoinduced Self-Repair of RNA Uracil Dimers.The journal of physical chemistry letters · 2026
    Article
  10. Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Quality control and signaling pathways at stalled ribosomes.Experimental & molecular medicine · 2026
    Review
  15. Article
  16. Review
  17. Three Novel Bacteriophages for the Biocontrol ofPathogens (Basel, Switzerland) · 2025
    Article
  18. Establishing an Improved Cellular Photoaging Model by Repeated UVA Exposure of Human Skin Fibroblasts.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025
    Article
  19. Article
  20. Article

97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elisabeth J WurtmannDepartment of Cell Biology, Yale University, New Haven, CT 06510, USA. elisabeth.wurtmann@yale.edu
Sandra L Wolin
Yale University · US

Funding

RNA quality control and environmental stressR01GM073863 · NIGMS · YALE UNIVERSITY · PI TSCHUDI, CHRISTIAN · 2005 to 2017
$3.6M
NIGMS NIH HHS GM073863NIGMS NIH HHS R01 GM073863
6 · The paper itself

Abstract

Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein crosslinking. In vitro studies have described a range of possible damage products, some of which are supported as physiologically relevant by in vivo observations in normal growth, stress conditions, or disease states. Damage to both messenger RNA and noncoding RNA may have functional consequences, and work has begun to elucidate the role of RNA turnover pathways and specific damage recognition pathways in clearing cells of these damaged RNAs.

Indexed as

AlkylationOxidative StressAnimalsHumansMetabolic Networks and PathwaysProteinsRNAUltraviolet RaysProteinsRNA

Identifiers

PMID19089684
PMCPMC2656420
OpenAlexW2169838876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.