ArticleNeuroscience and behavioral physiology2009
Long-term disorders of behavior in rats induced by administration of tumor necrosis factor during early postnatal ontogenesis.
Article in Neuroscience and behavioral physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Administration of Bacterial Lipopolysaccharide during Early Postnatal Ontogenesis Induces Transient Impairment of Long-Term Synaptic Plasticity Associated with Behavioral Abnormalities in Young Rats.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Reversal of established traumatic brain injury-induced, anxiety-like behavior in rats after delayed, post-injury neuroimmune suppression.Journal of neurotrauma · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) is one of the main mediators of neuroimmune interactions. Increased production of TNFalpha in nerve and immune system cells occurs in infectious diseases, traumas, ischemia, and hypoxia. The present study addressed the role of TNFalpha in the formation of behavior during early postnatal ontogenesis. TNFalpha was given to rats during the third week of life and behavior was tested at ages 1.5 and 3 months using the open field test and the elevated plus maze test. Experimental rats differed from controls in terms of changes in orientational behavior on testing at 1.5 months and an increase in anxiety on testing at 1.5 and 3 months. The different roles of proinflammatory cytokines in the brain at the early stages of ontogenesis are discussed.
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Registered trials
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