ArticleJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy2008
Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia.
Article in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis.Annals of family medicine · 2016Pooled it
- Incidence of viral infection detected by PCR and real-time PCR in childhood community-acquired pneumonia: a meta-analysis.Respirology (Carlton, Vic.) · 2015Pooled it
- The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Guideline
- Methodology and application of multiplex PCR-dipstick DNA chromatography for the detection of eight respiratory bacterial pathogens.Frontiers in cellular and infection microbiology · 2025Article
- Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment.Clinical and experimental pediatrics · 2024Article
- Establishment and Performance Evaluation of Multiplex PCR-Dipstick DNA Chromatography forThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Antibiotic use and outcomes among children hospitalized with suspected pneumonia.Journal of hospital medicine · 2022Article
- Evaluation of viral respiratory pathogens in children aged under five hospitalized with lower respiratory tract infections.Northern clinics of Istanbul · 2022Article
- Antibiotic Choice and Clinical Outcomes in Ambulatory Children with Community-Acquired Pneumonia.The Journal of pediatrics · 2021Article
- Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected Pneumonia.Pediatrics · 2020Article
- Fatal Primary Human Bocavirus Pneumonia in an Immunocompetent Adult.Internal medicine (Tokyo, Japan) · 2020Article
- Metagenomic analysis using next-generation sequencing of pathogens in bronchoalveolar lavage fluid from pediatric patients with respiratory failure.Scientific reports · 2019Article
- A case report on parainfluenza virus type 4a infection in a 1-year-old boy with biphasic fever.Journal of thoracic disease · 2018Article
- Detection of pathogens by real-time PCR in adult patients with acute exacerbation of bronchial asthma.BMC pulmonary medicine · 2017Article
- Missed opportunities for antimicrobial stewardship in pre-school children admitted to hospital with lower respiratory tract infection.Journal of paediatrics and child health · 2017Article
- Child pneumonia - focus on the Western Pacific Region.Paediatric respiratory reviews · 2017Review
- Human bocavirus: Current knowledge and future challenges.World journal of gastroenterology · 2016Review
- Beta-lactam versus beta- lactam/macrolide therapy in pediatric outpatient pneumonia.Pediatric pulmonology · 2016Article
- Time to reconsider routine high-dose amoxicillin for community-acquired pneumonia in all Canadian children.Paediatrics & child health · 2016Article
- Detection of respiratory viral and bacterial pathogens causing pediatric community-acquired pneumonia in Beijing using real-time PCR.Chronic diseases and translational medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed a real-time reverse transcription-PCR (RT-PCR) method to detect 13 respiratory viruses: influenza virus A and B; respiratory syncytial virus (RSV) subgroup A and B; parainfluenza virus (PIV) 1, 2, and 3; adenovirus; rhinovirus (RV); enterovirus; coronavirus (OC43); human metapneumovirus (hMPV); and human bocavirus (HBoV). The new method for detection of these viruses was applied simultaneously with real-time PCR for the detection of six bacterial pathogens in clinical samples from 1700 pediatric patients with community-acquired pneumonia (CAP). Of all the patients, 32.5% were suspected to have single bacterial infections; 1.9%, multiple bacterial infections; 15.2%, coinfections of bacteria and viruses; 25.8%, single viral infections; and 2.1%, multiple viral infections. In the remaining 22.6%, the etiology was unknown. The breakdown of suspected causative pathogens was as follows: 24.4% were Streptococcus pneumoniae, 14.8% were Mycoplasma pneumoniae, 11.3% were Haemophilus influenzae, and 1.4% were Chlamydophila pneumoniae. The breakdown of viruses was as follows: 14.5% were RV, 9.4% were RSV, 7.4% were hMPV, 7.2% were PIV, and 2.9% were HBoV. The new method will contribute to advances in the accuracy of diagnosis and should also result in the appropriate use of antimicrobials.
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