ArticleHuman genetics2009
Identification of genomic regions contributing to etoposide-induced cytotoxicity.
Article in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Structure and Function of Protein Arginine Methyltransferase PRMT7.Life (Basel, Switzerland) · 2021Review
- Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations.Human molecular genetics · 2021Article
- Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy.Frontiers in neurology · 2018Review
- Supervised classification of etoposide-treatedJournal of medical imaging (Bellingham, Wash.) · 2017Article
- Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop.The Journal of biological chemistry · 2014Article
- Role of PRMTs in cancer: Could minor isoforms be leaving a mark?World journal of biological chemistry · 2014Review
- A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes.Frontiers in genetics · 2014Article
- Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.The Journal of biological chemistry · 2013Article
- Multivariate methods and software for association mapping in dose-response genome-wide association studies.BioData mining · 2012Article
- A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.Pharmacogenetics and genomics · 2012Article
- Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues.The Journal of biological chemistry · 2012Article
- Impact of genetic polymorphisms on chemotherapy toxicity in childhood acute lymphoblastic leukemia.Frontiers in genetics · 2012Article
- Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.Pharmacogenetics and genomics · 2011Article
- Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen.International immunopharmacology · 2011Article
- Histone arginine methylation.FEBS letters · 2011Review
- The use of genomic information to optimize cancer chemotherapy.Seminars in oncology · 2011Review
- MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits.Cell proliferation · 2011Article
- A comparison of association methods for cytotoxicity mapping in pharmacogenomics.Frontiers in genetics · 2011Article
- Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.The pharmacogenomics journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Etoposide is routinely used in combination-based chemotherapy for testicular cancer and small-cell lung cancer; however, myelosuppression, therapy-related leukemia and neurotoxicity limit its utility. To determine the genetic contribution to cellular sensitivity to etoposide, we evaluated cell growth inhibition in Centre d' Etude du Polymorphisme Humain lymphoblastoid cell lines from 24 multi-generational pedigrees (321 samples) following treatment with 0.02-2.5 microM etoposide for 72 h. Heritability analysis showed that genetic variation contributes significantly to the cytotoxic phenotypes (h (2) = 0.17-0.25, P = 4.9 x 10(-5)-7.3 x 10(-3)). Whole genome linkage scans uncovered 8 regions with peak LOD scores ranging from 1.57 to 2.55, with the most significant signals being found on chromosome 5 (LOD = 2.55) and chromosome 6 (LOD = 2.52). Linkage-directed association was performed on a subset of HapMap samples within the pedigrees to find 22 SNPs significantly associated with etoposide cytotoxicity at one or more treatment concentrations. UVRAG, a DNA repair gene, SEMA5A, SLC7A6 and PRMT7 are implicated from these unbiased studies. Our findings suggest that susceptibility to etoposide-induced cytotoxicity is heritable and using an integrated genomics approach we identified both genomic regions and SNPs associated with the cytotoxic phenotypes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.