ArticleMethods in molecular biology (Clifton, N.J.)2009
Isolation and characterization of hepatic stem cells, or "oval cells," from rat livers.
Article in Methods in molecular biology (Clifton, N.J.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Advanced therapy to cure diabetes: mission impossible is now possible?Frontiers in cell and developmental biology · 2024Review
- p53 positively regulates the proliferation of hepatic progenitor cells promoted by laminin-521.Signal transduction and targeted therapy · 2022Article
- Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells.Cells · 2020Article
- Advances in Hepatic Tissue Bioengineering with Decellularized Liver Bioscaffold.Stem cells international · 2019Review
- Expression of receptor interacting protein 1 and receptor interacting protein 3 oval cells in a rat model of hepatocarcinogenesis.Experimental and therapeutic medicine · 2018Article
- Directed Differentiation of Adult Liver Derived Mesenchymal Like Stem Cells into Functional Hepatocytes.Scientific reports · 2018Article
- A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver.Scientific reports · 2017Article
- Multi-organ Mapping of Cancer Risk.Cell · 2016Article
- New Tools in Experimental Cellular Therapy for the Treatment of Liver Diseases.Current transplantation reports · 2015Article
- An efficient protocol for deriving liver stem cells from neonatal mice: validating its differentiation potential.Analytical cellular pathology (Amsterdam) · 2015Article
- Unbalanced distribution of materials: the art of giving rise to hepatocytes from liver stem/progenitor cells.Journal of cellular and molecular medicine · 2014Review
- Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice.Hepatology (Baltimore, Md.) · 2011Article
- MRI of magnetically labeled mesenchymal stem cells in hepatic failure model.World journal of gastroenterology · 2010Article
- Stem cell origins and animal models of hepatocellular carcinoma.Digestive diseases and sciences · 2010Review
- Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.Journal of hepatology · 2009Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The pace of research on the potential therapeutic uses of liver stem cells or "oval cells" has accelerated significantly in recent years. Concurrent advancements in techniques for the isolation and characterization of these cells have helped fuel this research. Several models now exist for the induction of oval cell proliferation in rodents. Protocols for the isolation and culture of these cells have evolved to the point that they may be set up in any laboratory equipped for cell culture. The advent of magnetic cell sorting has eliminated reliance on expensive flow cytometric sorting equipment to generate highly enriched populations of oval cells. Our laboratory has had much success in using the oval cell surface marker Thy-1 in combination with magnetic sorting to produce material suitable for testing the influence of a myriad of chemical signaling molecules on the oval cell phenotype. This chapter will describe our basic strategy for oval cell induction and isolation. Additionally, two in vitro procedures are described which the reader may find useful in the early stages of developing an oval cell research project.
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