Evidence map›Paper›PMID 19088274›Full record

ArticleThe Journal of general virology2009

Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments.

Nigel D Stow, Vanessa C Evans, David A Matthews

Open access · hybridAbstract read
In one paragraph

Article in The Journal of general virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Viruses and the nucleolus: the fatal attraction.Biochimica et biophysica acta · 2014
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Proteomics analysis of the nucleolus in adenovirus-infected cells.Molecular & cellular proteomics : MCP · 2010
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nigel D StowMRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK.
Vanessa C Evans
David A Matthews
University of Bristol · GB

Funding

Medical Research Council MC_U130115828Wellcome TrustWellcome Trust 083604
6 · The paper itself

Abstract

Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.

Indexed as

Virus ReplicationDNA ReplicationDNA, ViralHeLa CellsHerpesvirus 1, HumanHumansPol1 Transcription Initiation Complex ProteinsDNA, ViralPol1 Transcription Initiation Complex Proteinstranscription factor UBF

Identifiers

PMID19088274
PMCPMC2885023
OpenAlexW2058796068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.