ArticleInfection and immunity1991
Effects of activated macrophages on Mycobacterium leprae.
Article in Infection and immunity, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Susceptibility and resistance in leprosy: Studies in the mouse model.Immunological reviews · 2021Review
- Molecular assays for determining Mycobacterium leprae viability in tissues of experimentally infected mice.PLoS neglected tropical diseases · 2013Article
- IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians.Human genetics · 2010Article
- Molecular determination of Mycobacterium leprae viability by use of real-time PCR.Journal of clinical microbiology · 2009Article
- Mycobacterium leprae is naturally resistant to PA-824.Antimicrobial agents and chemotherapy · 2006Article
- The continuing challenges of leprosy.Clinical microbiology reviews · 2006Review
- Effects of thalidomide on intracellular Mycobacterium leprae in normal and activated macrophages.Clinical and diagnostic laboratory immunology · 2005Article
- Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.Infection and immunity · 2000Article
- Effects of essential fatty acid deficiency on prostaglandin E2 production and cell-mediated immunity in a mouse model of leprosy.Infection and immunity · 1997Article
- Fusidic acid is highly active against extracellular and intracellular Mycobacterium leprae.Antimicrobial agents and chemotherapy · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Five alternative methods were used to explore in vitro the effects of normal and activated murine macrophages on the metabolic well-being of intracellular Mycobacterium leprae: fluorescein diacetate-ethidium bromide staining, ATP content, synthesis of phenolic glycolipid 1, and two techniques to quantitate oxidation of palmitic acid. In relatively short-term experiments (7 to 10 days), each of these procedures provided strong evidence that activated macrophages exerted a deleterious effect on the leprosy bacillus. These findings appear to confirm the contention that activated macrophages underlie host resistance to clinical leprosy and limitation of M. leprae growth in paucibacillary leprosy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.