ArticleGenetics2009
Polymorphism due to multiple amino acid substitutions at a codon site within Ciona savignyi.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Prevalence of multinucleotide replacements in evolution of primates and Drosophila.Molecular biology and evolution · 2013Article
- Maize microarray annotation database.Plant methods · 2011Article
- Pervasive multinucleotide mutational events in eukaryotes.Current biology : CB · 2011Article
- Accelerated evolutionary rate of housekeeping genes in tunicates.Journal of molecular evolution · 2010Article
- The rate of establishment of complex adaptations.Molecular biology and evolution · 2010Article
- Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We compared two haploid genotypes of one Ciona savignyi individual and identified codons at which these genotypes differ by two nonsynonymous substitutions. Using the C. intestinalis genome as an outgroup, we showed that both substitutions tend to occur in the same genotype. Only in 53 (34.4%) of 154 codons, one substitution occurred in each of the two genotypes, although 77 (50%) of such codons are to be expected if substitutions were independent. We considered two feasible evolutionary causes for the observed pattern: substitutions driven by positive selection and compensatory substitutions, as well as several potential biases. However, none of these explanations is fully compelling, and data on multiple genotypes of C. savignyi would help to elucidate the causes of this pattern.
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