ArticleBMC medical genetics2008
Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- GABRG2 mutations in genetic epilepsy with febrile seizures plus: structure, roles, and molecular genetics.Journal of translational medicine · 2024Review
- Molecular and Cellular Neurobiology of Circadian and Circannual Rhythms in Migraine: A Narrative Review.International journal of molecular sciences · 2023Review
- Contributions of Nociresponsive Area 3a to Normal and Abnormal Somatosensory Perception.The journal of pain · 2019Review
- Increased thalamic glutamate/glutamine levels in migraineurs.The journal of headache and pain · 2018Article
- Epilepsy and migraine-Are they comorbidity?Genes & diseases · 2018Review
- Gamma-aminobutyric acid (GABA) receptors GABRA4, GABRE, and GABRQ gene polymorphisms and risk for migraine.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Application of microRNA and mRNA expression profiling on prognostic biomarker discovery for hepatocellular carcinoma.BMC genomics · 2014Article
- Headache and epilepsy.Current pain and headache reports · 2013Review
- mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway.Translational psychiatry · 2013Article
- Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.PloS one · 2013Article
- Identification of molecular genetic factors that influence migraine.Molecular genetics and genomics : MGG · 2011Review
- Common variants in the regulative regions of GRIA1 and GRIA3 receptor genes are associated with migraine susceptibility.BMC medical genetics · 2010Article
- Article
- Molecular genetics of migraine.Human genetics · 2009Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24-28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24-28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type epsilon (GABRE) and type theta (GABRQ) genes and their involvement in migraine.
methodsWe have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.
resultsOur study did not show any association between the examined SNPs in our test population (P>0.05).
conclusionAlthough these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.
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